ArticleJournal of cancer research and clinical oncology1993
Characterization of integrin subunits, cellular adhesion and tumorgenicity of four human prostate cell lines.
Article in Journal of cancer research and clinical oncology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 116 citations in OpenAlex.
- Honey reduces the metastatic characteristics of prostate cancer cell lines by promoting a loss of adhesion.PeerJ · 2018Article
- Characterization of Laminin Binding Integrin Internalization in Prostate Cancer Cells.Journal of cellular biochemistry · 2017Article
- Triiodothyronine Attenuates Prostate Cancer Progression Mediated by β-Adrenergic Stimulation.Molecular medicine (Cambridge, Mass.) · 2016Article
- Derivation of Porcine Embryonic Stem-Like Cells from In Vitro-Produced Blastocyst-Stage Embryos.Scientific reports · 2016Article
- miR-138-Mediated Regulation of KINDLIN-2 Expression Modulates Sensitivity to Chemotherapeutics.Molecular cancer research : MCR · 2016Article
- Recombinant disintegrin domain of human ADAM9 inhibits migration and invasion of DU145 prostate tumor cells.Cell adhesion & migration · 2015Article
- Rad9 protein contributes to prostate tumor progression by promoting cell migration and anoikis resistance.The Journal of biological chemistry · 2012Article
- Article
- Prostate-derived Ets transcription factor (PDEF) is a potential prognostic marker in patients with prostate cancer.The Prostate · 2011Article
- Individual rac GTPases mediate aspects of prostate cancer cell and bone marrow endothelial cell interactions.Journal of signal transduction · 2011Article
- Culture conditions and signalling networks promoting the establishment of cell lines from parthenogenetic and biparental pig embryos.Stem cell reviews and reports · 2010Article
- Identification of vitronectin as an extrinsic inducer of cancer stem cell differentiation and tumor formation.Stem cells (Dayton, Ohio) · 2010Article
- Serum CXCL13 positively correlates with prostatic disease, prostate-specific antigen and mediates prostate cancer cell invasion, integrin clustering and cell adhesion.Cancer letters · 2009Article
- Identification of a small molecule class to enhance cell-cell adhesion and attenuate prostate tumor growth and metastasis.Molecular cancer therapeutics · 2009Article
- Evaluation of the expression of integrins and cell adhesion molecules through tissue microarray in lymph node metastases of prostate cancer.Journal of carcinogenesis · 2009Article
- Involvement of Cyr61 in growth, migration, and metastasis of prostate cancer cells.British journal of cancer · 2008Article
- AFAP-110 is overexpressed in prostate cancer and contributes to tumorigenic growth by regulating focal contacts.The Journal of clinical investigation · 2007Article
- Article
- Bone microenvironment modulates expression and activity of cathepsin B in prostate cancer.Neoplasia (New York, N.Y.) · 2005Article
- Changes in extracellular matrix (ECM) and ECM-associated proteins in the metastatic progression of prostate cancer.Reproductive biology and endocrinology : RB&E · 2004Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Cellular adhesion to extracellular matrix proteins via integrin molecules is a major factor in the process of invasion and metastasis of human tumor cells. Four human prostate cell lines were characterized according to the presence and quantity of integrin subunits, the ability of the cells to attach to extracellular substrates and the capacity of the cells to form tumors in severe combined immunodeficient (SCID) mice. All four human prostate cell lines expressed three to five integrins on their cell surfaces. The DU145, PC3 and 431P cells expressed primarily alpha 3, alpha 5, and alpha 6 integrin at similar levels. These cell lines expressed the subunits beta 1, beta 3, and beta 4 with beta 1 predominant. The DU145 cells preferred attachment to fibronectin, followed by laminin and vitronectin. Approximately 50%-60% of the binding of DU145 cells to fibronectin and laminin was dependent on the function of alpha 5 beta 1 and alpha 6 respectively. The cell line LNCaP differed in its low expression of the alpha 3 subunit, 95% of cellular adhesion to fibronectin and laminin being integrin-dependent and its inability to attach to vitronectin, in spite of surface expression of alpha v beta 3. All the cell lines except for LNCaP readily formed tumors within SCID mice and the expression of alpha 3, alpha 6, beta 1 and beta 4 integrin subunits was preserved in the resulting tumor tissue. The altered adhesion properties of the LNCaP cells may explain their altered tumorigenicity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.