ArticleClinical and experimental immunology1993
Changes in natural immunity during the course of HIV-1 infection.
Article in Clinical and experimental immunology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 38 citations in OpenAlex.
- CD3Journal of neuroimmunology · 2023Article
- The impact of HIV-1 infection and exposure on natural killer (NK) cell phenotype in Kenyan infants during the first year of life.Frontiers in immunology · 2012Article
- Natural-killer cell-derived cytolytic molecules in HIV-associated pulmonary tuberculosis-role of exogenous interleukins.Journal of clinical immunology · 2010Article
- Natural killer cells in perinatally HIV-1-infected children exhibit less degranulation compared to HIV-1-exposed uninfected children and their expression of KIR2DL3, NKG2C, and NKp46 correlates with disease severity.Journal of immunology (Baltimore, Md. : 1950) · 2007Article
- Differential expression of perforin in cytotoxic lymphocyte in HIV/AIDS patients of China.Journal of clinical immunology · 2006Article
- Dendritic cells and natural killer cells in the pathogenesis of HIV infection.Immunologic research · 2005Review
- Natural killer cells in HIV-1 infection: dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Persistent HIV-1 infection of natural killer cells in patients receiving highly active antiretroviral therapy.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Persistence and fitness of multidrug-resistant human immunodeficiency virus type 1 acquired in primary infection.Journal of virology · 2002Article
- Reversal of human immunodeficiency virus type 1 protein-induced inhibition of natural killer cell activity by alpha interferon and interleukin-2.Clinical and diagnostic laboratory immunology · 2000Article
- Heat shock protein-based therapeutic strategies against human immunodeficiency virus type 1 infection.Infectious diseases in obstetrics and gynecology · 1999Review
- Combined in vitro effect of marijuana and retrovirus on the activity of mouse natural killer cells.Pathology oncology research : POR · 1998Article
- Interleukin-2 and human immunodeficiency virus infection: pathogenic mechanisms and potential for immunologic enhancement.Immunologic research · 1996Review
- Defective natural immunity: an early manifestation of human immunodeficiency virus infection.The Journal of experimental medicine · 1995Article
- Interleukin-2-inducible natural immune (lymphokine-activated killer cell) responses as a functional correlate of progression to AIDS.Clinical and diagnostic laboratory immunology · 1994Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of natural killer (NK) and lymphokine-activated killer (LAK) cell-mediated cytotoxicity in AIDS has yet to be established. The objective of this study was to determine inducible LAK cell responses at different stages of HIV-1 infection, and specifically to establish the participation of CD8 lymphocytes in these responses. Peripheral blood lymphocytes (PBL) were isolated from healthy seronegative (CDC-0) subjects and HIV-1+ individuals who were clinically asymptomatic (Centre for Disease Control group 2, CDC-2) or symptomatic (CDC-4) with regard to secondary opportunistic infection (OI). LAK cells were generated upon incubation of PBL with IL-2 and their cytolysis of K562 and U-937 targets was determined using chromium release assays. The role of CD8+ lymphocytes as progenitors and effectors of these LAK cell responses was determined by immunomagnetic depletion of CD8+ cells from precursor PBL and LAK cells, respectively. LAK cell-mediated cytotoxicities in HIV-1-infected individuals were reduced compared with seronegative controls without any corresponding changes in the relative proportions of CD56+ (NK) cells among groups. Depletions of CD8+ subsets from either PBL or LAK cells dramatically reduced total LAK cytotoxic responses and LAK activities per unit CD56+ cell in the OI-/CDC-2 seropositive population. No corresponding changes in LAK activities in seronegative control or HIV+/OI+/CDC-4 groups were observed. Levels of LAK activity against K562 targets in CDC-0/HIV- and CDC-4/HIV+ groups correlated with the percentage of CD56+ LAK cells; corresponding LAK activity in the CDC-2/HIV+ group correlated with the percentage of both CD56+ and CD8+ subsets. These findings suggest that adaptive changes in non-MHC restricted cytotoxic responses occur in HIV-1 individuals at early stages post-HIV infection, before the onset of opportunistic infection.
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