ArticleThe EMBO journal1993
Targeted expression of a dominant-negative FGF receptor mutant in the epidermis of transgenic mice reveals a role of FGF in keratinocyte organization and differentiation.
Article in The EMBO journal, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
67 citing papers in PubMed, 242 citations in OpenAlex.
- Opposite sex housing enhances reproductive function and induces transcriptional changes in the preoptic area of GnRH-deficient mice.Frontiers in endocrinology · 2025Article
- Systemic Inflammatory Proteomic Biomarkers in Atopic Dermatitis: Exploring Potential Indicators for Disease Severity.Journal of Korean medical science · 2024Article
- Suppression of BMP signaling restores mitral cell development impaired by FGF signaling deficits in mouse olfactory bulb.Molecular and cellular neurosciences · 2024Article
- Botox (onabotulinumtoxinA) mechanism of action.Medicine · 2023Article
- Acute and chronic effects of a light-activated FGF receptor in keratinocytes in vitro and in mice.Life science alliance · 2021Article
- Mouse genetics identifies unique and overlapping functions of fibroblast growth factor receptors in keratinocytes.Journal of cellular and molecular medicine · 2020Article
- Dualism of FGF and TGF-β Signaling in Heterogeneous Cancer-Associated Fibroblast Activation with ETV1 as a Critical Determinant.Cell reports · 2019Article
- Secretory phospholipase AScientific reports · 2017Article
- Smad7 regulates compensatory hepatocyte proliferation in damaged mouse liver and positively relates to better clinical outcome in human hepatocellular carcinoma.Clinical science (London, England : 1979) · 2015Article
- Dermatan sulfate epimerase 1 deficient mice as a model for human abdominal wall defects.Birth defects research. Part A, Clinical and molecular teratology · 2014Article
- Human pigmentation: A side effect adapted from a primitive organism's survival. Part 2: The melanocyte as mentor of the keratinocye.Indian dermatology online journal · 2014Article
- Activation of Nrf2 in keratinocytes causes chloracne (MADISH)-like skin disease in mice.EMBO molecular medicine · 2014Article
- A Network Map of FGF-1/FGFR Signaling System.Journal of signal transduction · 2014Review
- Opposite-sex housing reactivates the declining GnRH system in aged transgenic male mice with FGF signaling deficiency.American journal of physiology. Endocrinology and metabolism · 2012Article
- Transgenic mouse model expressing tdTomato under involucrin promoter as a tool for analysis of epidermal differentiation and wound healing.Transgenic research · 2012Article
- FGF signaling expands embryonic cortical surface area by regulating Notch-dependent neurogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- The adhesion molecule NCAM promotes ovarian cancer progression via FGFR signalling.EMBO molecular medicine · 2011Article
- Fibroblast growth factors: biology, function, and application for tissue regeneration.Journal of tissue engineering · 2010Article
- Nrf2 establishes a glutathione-mediated gradient of UVB cytoprotection in the epidermis.Genes & development · 2010Article
- Fibroblast growth factor receptors 1 and 2 in keratinocytes control the epidermal barrier and cutaneous homeostasis.The Journal of cell biology · 2010Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
In this study we used a dominant-negative FGF receptor mutant to block FGF function in a specific tissue of transgenic mice. The mutant receptor, which is known to block signal transduction in cells when co-expressed with wild-type receptors, was targeted to suprabasal keratinocytes using a keratin 10 promoter. The transgene was expressed specifically in the skin and highest expression levels were found in the tail. Expression of the mutant receptor disrupted the organization of epidermal keratinocytes, induced epidermal hyperthickening and resulted in an aberrant expression of keratin 6. This suggests that FGF is essential for the morphogenesis of suprabasal keratinocytes and for the establishment of the normal program of keratinocyte differentiation. Our study demonstrates that dominant-negative growth factor receptors can be used to block selectively the action of a growth factor in specific tissues of transgenic mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.