ArticleExperimental brain research1993
Expression of neuropeptides and neuropeptide mRNAs in spinal cord after axotomy in the rat, with special reference to motoneurons and galanin.
Article in Experimental brain research, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 73 citations in OpenAlex.
- Restoring early postnatal synaptic dysregulation rescues motor neuron degeneration in a mouse model of Spinal and Bulbar Muscular Atrophy.Nature communications · 2026Article
- The Galaninergic System: A Target for Cancer Treatment.Cancers · 2022Review
- Galanin family peptides: Molecular structure, expression and roles in the neuroendocrine axis and in the spinal cord.Frontiers in endocrinology · 2022Review
- Peripheral nerve injury induced changes in the spinal cord and strategies to counteract/enhance the changes to promote nerve regeneration.Neural regeneration research · 2020Article
- Botulinum toxin type A in motor nervous system: unexplained observations and new challenges.Journal of neural transmission (Vienna, Austria : 1996) · 2016Review
- Galanin receptors and ligands.Frontiers in endocrinology · 2012Article
- Triggering genetically-expressed transneuronal tracers by peripheral axotomy reveals convergent and segregated sensory neuron-spinal cord connectivity.Neuroscience · 2009Article
- Galanin transgenic mice display cognitive and neurochemical deficits characteristic of Alzheimer's disease.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Galanin: neurobiologic mechanisms and therapeutic potential for Alzheimer's disease.CNS drug reviews · 2001Review
- Targeted disruption of the galanin gene reduces the number of sensory neurons and their regenerative capacity.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Vasoactive intestinal peptide and pituitary adenylyl cyclase-activating polypeptide inhibit tumor necrosis factor-alpha production in injured spinal cord and in activated microglia via a cAMP-dependent pathway.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Effects of irradiation on neuropeptide expression in rat salivary gland and spinal cord.The Histochemical journal · 1994Article
- Calcitonin gene-related peptide-like immunoreactivity in motoneuron pools innervating different hind limb muscles in the rat.Experimental brain research · 1993Article
- Neuropeptide messenger plasticity in the CNS neurons following axotomy.Molecular neurobiologyReview
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5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The extent to which the plasticity in peptide expression observed in developing spinal motoneurons occurs following proximal peripheral axotomy in the adult rat was examined using in situ hybridization and immunohistochemical techniques to visualize the changes. Transient upregulation of galanin, vasoactive intestinal polypeptide (VIP) and substance P messenger ribonucleic acids (mRNAs) was observed within subpopulations of motoneurons ipsilateral to lesion for periods lasting 2-3 weeks after injury. In contrast, the axotomy-induced heterogenous increases in somatostatin and neuropeptide tyrosine mRNA expression in ipsilateral motoneurons remained elevated, or, in the case of somatostatin, continued to increase for the time period studied (1 month). Immunohistochemical analysis agreed with the in situ hybridization results, showing some motoneurons within the injured ventral horn to contain galanin-, VIP- or somatostatin-like immunoreactivity. In some instances, galanin-immunoreactive motoneurons colocalized with calcitonin gene-related peptide immunoreactivity. Most of the neurons expressing the injury-induced peptides appeared large, presumably alpha-motoneurons but there were also many small neurons expressing galanin in the ventral horn ipsilateral to lesion. This may represent evidence for peptide synthesis in gamma-motoneurons. The only peptide mRNA studied to be down-regulated in response to axotomy was enkephalin. The results show that peptide expression in injured motoneurons is dramatically altered, the significance of which remains to be determined.
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