ArticleBritish heart journal1993
Innervation of the human cardiac conduction system at birth.
Article in British heart journal, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Innervation of the Human Atrioventricular Node via the Inferior Pyramidal Space: Characterization Using Intersectional Strategies.Circulation. Arrhythmia and electrophysiology · 2026Article
- Exploring the prospects, advancements, and challenges ofFrontiers in cellular neuroscience · 2024Article
- The presence of mu-, delta-, and kappa-opioid receptors in human heart tissue.Heart and vessels · 2014Article
- Cardiac innervation and sudden cardiac death.Current cardiology reviews · 2009Article
- Localisation and quantitation of autonomic innervation in the porcine heart I: conduction system.Journal of anatomy · 1999Article
- Postmortem changes in the immunohistochemical demonstration of nerves in human ventricular myocardium.Journal of anatomy · 1998Article
- The innervation of the human myocardium at birth.Journal of anatomy · 1995Article
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4 authors.
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Abstract
objectiveTo study the pattern of innervation of the conduction system of the neonatal heart in humans.
designA prospective analysis based on immunohistochemical and enzyme histochemical examination of newborn human hearts.
settingA general district hospital.
main outcome measuresFresh necropsy tissue. MATERIAL: Hearts of three neonatal humans with no cardiac anomaly, freshly taken at necropsy.
methodsSerial sectioning to obtain a three dimensional reconstruction of the cardiac conduction system, followed by identification of the pattern of innervation by immunohistochemical and enzyme histochemical techniques; with a panel of antisera against protein gene product (PGP) 9.5 as a general neural indicator; dopamine beta-hydroxylase (DBH) and tyrosine hydroxylase (TH) as indicators for sympathetic neural tissue; and selected neuropeptides--namely, neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP), calcitonin gene related peptide (CGRP), and substance P (SP). Gomori's technique was used for locating cholinesterase activity.
resultsPGP immunoreactive (PGP-IR) nerves were present in large numbers in the sinus node, atrioventricular (AV) node, and penetrating atrioventricular bundle; in moderate numbers in the branching bundle; and occasionally in the bundle branches. Small numbers of DBH-IR and TH-IR nerves were seen in the sinus and AV nodes, mainly perivascularly; there were few in the penetrating and branching bundles and none in the bundle branches. A few perivascular NPY-IR nerves were seen only in the sinus node. VIP-IR, CGRP-IR, and SP-IR nerves were not seen. Pseudocholinesterase activity was found in the conduction tissue, whereas occasional acetylcholinesterase positive nerves were found only in the sinus and AV nodes.
conclusionA considerable innervation of the human cardiac conduction system is present at birth, although, by comparison with the results of other studies on adult tissue, the mature pattern has not yet been established. Thus it is still in the process of maturation, especially with regard to the acquisition of various neurotransmitters, including the more recently described neuropeptides.
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