ArticleJournal of virology1993
A model system for nonhomologous recombination between retroviral and cellular RNA.
Article in Journal of virology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Using Haplotype-Based Artificial Intelligence to Evaluate SARS-CoV-2 Novel Variants and Mutations.JAMA network open · 2023Article
- Review
- LTR-mediated retroposition as a mechanism of RNA-based duplication in metazoans.Genome research · 2016Article
- The Host RNAs in Retroviral Particles.Viruses · 2016Review
- Acutely transforming retrovirus expressing Nras generated from HT-1080 fibrosarcoma cells infected with the human retrovirus XMRV.Journal of virology · 2010Article
- The remarkable frequency of human immunodeficiency virus type 1 genetic recombination.Microbiology and molecular biology reviews : MMBR · 2009Review
- Effects of identity minimization on Moloney murine leukemia virus template recognition and frequent tertiary template-directed insertions during nonhomologous recombination.Journal of virology · 2007Article
- Virion packaging determinants and reverse transcription of SRP RNA in HIV-1 particles.Nucleic acids research · 2007Article
- Evidence for the acquisition of multi-drug resistance in an HIV-1 clinical isolate via human sequence transduction.Virology · 2006Article
- Human immunodeficiency virus type 1 transductive recombination can occur frequently and in proportion to polyadenylation signal readthrough.Journal of virology · 2004Article
- Packaging and reverse transcription of snRNAs by retroviruses may generate pseudogenes.RNA (New York, N.Y.) · 2004Article
- Nucleocapsid-RNA interactions are essential to structural stability but not to assembly of retroviruses.Journal of virology · 2004Article
- Transduction of cellular sequence by a human immunodeficiency virus type 1-derived vector.Journal of virology · 2001Article
- Genomic stability of murine leukemia viruses containing insertions at the Env-3' untranslated region boundary.Journal of virology · 2001Article
- DNA integration by Ty integrase in yku70 mutant Saccharomyces cerevisiae cells.Molecular and cellular biology · 2000Article
- Evolution and horizontal transfer of dUTPase-encoding genes in viruses and their hosts.Journal of virology · 1999Article
- Article
- RNA-RNA recombination in Sindbis virus: roles of the 3' conserved motif, poly(A) tail, and nonviral sequences of template RNAs in polymerase recognition and template switching.Journal of virology · 1997Article
- Homologous and nonhomologous retroviral recombinations are both involved in the transfer by infectious particles of defective avian leukosis virus-derived transcomplementing genomes.Journal of virology · 1996Article
- The recombination rate is not increased when retroviral RNA is missing an encapsidation sequence.Journal of virology · 1996Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
A current model for the generation of transforming retroviruses proposes that read-through RNAs, containing both viral and cellular sequences, are copackaged with viral genomic RNA. It is, however, possible that a cellular mRNA is occasionally encapsidated into a retroviral particle, even though viral packaging sequences are absent. We have generated recombinant proviruses following copackaging of an avian leukosis viral genomic RNA and a neo-containing RNA completely devoid of retroviral sequences. In these studies, we used the packaging cell line SE21Q1b, which has the unique ability to randomly package cellular mRNA into retroviral particles. We describe 10 recombinants obtained following copackaging of nonhomologous RNAs. Our data show that recombination is not occurring at the DNA level in the parental SE21Q1b cells but is occurring at the RNA level, during reverse transcription. These data further suggest that reverse transcriptase can preferentially jump between templates at short stretches of homology in otherwise unrelated RNAs. We conclude that retroviral sequences are not required for packaged mRNA to be reverse transcribed and to be included in integrated proviruses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.