ArticleJournal of anatomy1993
Morphological observations on pancreatic islet blood vessels in low-dose streptozocin-treated mice.
Article in Journal of anatomy, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- Pancreatic duct inflammatory infiltration in the nonobese diabetic (NOD) mouse.Journal of anatomy · 1994Article
- Intercellular adhesion molecule-1 (ICAM-1) expression in the islets of the non-obese diabetic and low-dose streptozocin-treated mouse.Histochemistry · 1994Article
- The immunosuppressant FK506 inhibits the damage to mouse pancreatic islets induced by low dose streptozocin.Cell and tissue research · 1994Article
- Early insulitis and the islet vascular system.Diabetologia · 1993Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to observe modifications occurring within the blood vessels of pancreatic islets in low-dose streptozocin (STZ)-treated mice. Forty-two male C57BL/6J mice were given 40 mg STZ on 5 consecutive days and killed 6 or 10 d after the first STZ injection. Immunocytochemistry revealed a dense accumulation of cells carrying the 7D10 epitope, related to macrophage inhibitor factor, arranged around the 'vascular pole' of the islets on d 6, and a small number of positive cells within the islets on d 10. Many Ia positive cells (equivalent to MHC class II antigen positive elements) were also found at the periphery of the islet. Ultrastructural observations showed the presence of monocytes within almost all the capillary vessels encircling the islets and entering them at the 'vascular pole' (d 6). On d 10 capillary lumina no longer contained marginating monocytes but activated macrophages were seen in the islet parenchyma.
Indexed as
Identifiers
7685331PMC1259782W6539829What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.