ArticleMolecular biology of the cell1993
Transcriptional repression by the Rb-related protein p107.
Article in Molecular biology of the cell, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 102 citations in OpenAlex.
- Tumor Syndromes Predisposing to Osteosarcoma.Advances in anatomic pathology · 2018Review
- Targeting nucleocytoplasmic transport in cancer therapy.Oncotarget · 2014Review
- The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle.Cell division · 2012Article
- Murine models and cell lines for the investigation of pheochromocytoma: applications for future therapies?Endocrine pathology · 2012Review
- Structure-function analysis of the retinoblastoma tumor suppressor protein - is the whole a sum of its parts?Cell division · 2007Article
- Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130.Genes & development · 2004Article
- Differential control of transcription by DNA-bound cyclins.Molecular biology of the cell · 2001Article
- Control of E2F activity by p21Waf1/Cip1.Oncogene · 1999Article
- Cumulative effect of phosphorylation of pRB on regulation of E2F activity.Molecular and cellular biology · 1999Article
- Rapid dephosphorylation of p107 following UV irradiation.Oncogene · 1999Article
- Integration of a growth-suppressing BTB/POZ domain protein with the DP component of the E2F transcription factor.The EMBO journal · 1999Article
- CDF-1, a novel E2F-unrelated factor, interacts with cell cycle-regulated repressor elements in multiple promoters.Nucleic acids research · 1997Article
- The differential binding of E2F and CDF repressor complexes contributes to the timing of cell cycle-regulated transcription.Nucleic acids research · 1997Article
- Subunit composition determines E2F DNA-binding site specificity.Molecular and cellular biology · 1997Article
- Control of S-phase periodic transcription in the fission yeast mitotic cycle.The EMBO journal · 1997Article
- Molecular cloning and expression pattern of the DP members of the chicken E2F transcription factor.Gene expression · 1997Article
- Anchorage-dependent transcription of the cyclin A gene.Molecular and cellular biology · 1996Article
- Cyclin A expression is under negative transcriptional control during the cell cycle.Molecular and cellular biology · 1996Article
- Transcriptional repression and growth suppression by the p107 pocket protein.Molecular and cellular biology · 1996Article
- The E2F transcription factor activates a replication-dependent human H2A gene in early S phase of the cell cycle.Molecular and cellular biology · 1996Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transcription factor DRTF1/E2F is believed to play an important role in regulating cellular proliferation because it undergoes a series of periodic interactions with proteins that are known to be important regulators of the cell cycle, including the retinoblastoma gene product (pRb) and cyclin A. Furthermore, certain viral oncogene products, such as adenovirus E1a, disrupt these DRTF1/E2F complexes by sequestering the associated proteins. p107, a protein that is structurally related to pRb, also binds to DRTF1/E2F, and in this study we investigate the functional consequences of this interaction. We show that p107 can repress E2F binding site-dependent transcription and that the adenovirus E1a protein overcomes p107-mediated transcriptional repression. Two distinct but related proteins, pRb and p107, can therefore repress transcription driven by DRTF1/E2F, whereas the E1a protein overrides the repression. We also demonstrate that the transcription repressing properties of p107 and pRb are influenced by the cell type and by differentiation, because neither protein affects transcription in F9 embryonal carcinoma (EC) cells but both do so efficiently in differentiated derivatives. In this respect, the repressing activities of pRb and p107 inversely correlate with the presence of the cellular E1a-like activity previously documented in F9 EC cells. These data suggest that p107 and pRb exert their biological activities in some but not all cell types.
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