Evidence map›Paper›PMID 7684835›Full record

ArticleNucleic acids research1993

The exon trapping assay partly discriminates against alternatively spliced exons.

A Andreadis, P E Nisson, K S Kosik, P C Watkins

Open access · bronzeAbstract read
In one paragraph

Article in Nucleic acids research, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Tau Isoforms: Gaining Insight intoInternational journal of molecular sciences · 2022
    Review
  5. Regulation of human MAPT gene expression.Molecular neurodegeneration · 2015
    Review
  6. Use of an exon-trapping vector for the evaluation of splice-site mutations.Mammalian genome : official journal of the International Mammalian Genome Society · 2007
    Article
  7. Isolation of coding sequences from bovine cosmids by means of exon trapping.Mammalian genome : official journal of the International Mammalian Genome Society · 1997
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

A AndreadisDepartment of Neurology (Neuroscience), Harvard Medical School, Boston, MA.
P E Nisson
K S Kosik
P C Watkins
Brigham and Women's Hospital · USHarvard University · US

Funding

THE PATHOBIOLOGY OF TAU PROTEINR01AG006601 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI KOSIK, KENNETH S · 1987 to 1999
–
NIA NIH HHS AG06601
6 · The paper itself

Abstract

A cosmid containing eight exons of the gene coding for the microtubule-associated tau protein was subjected to the exon trapping assay. All the constitutive exons contained in the cosmid (4, 5, 7 and 9) were efficiently captured regardless of size. Of the four alternatively spliced exons, three (3, 4A and 8) were not isolated by the assay, but the behavior of exon 6 depended on the identity of its flanking exons.

Indexed as

Alternative SplicingExonsAmino Acid SequenceAnimalsBacterial ProteinsBase SequenceCell LineCloning, MolecularDNAHumansMolecular Sequence DataPolymerase Chain ReactionRNABacterial ProteinsDNARNAtus protein, Bacteria

Identifiers

PMID7684835
PMCPMC309487
OpenAlexW2000052455

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.