ArticleHistochemistry1993
Demonstration of cytokeratin intermediate filaments in oocytes of the developing and adult human ovary.
Article in Histochemistry, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 59 citations in OpenAlex.
- Generation of healthy bovine ovarian organoids: a proof-of-concept derivation technique.Journal of ovarian research · 2025Article
- Molecular manipulation of keratin 8/18 intermediate filaments: modulators of FAS-mediated death signaling in human ovarian granulosa tumor cells.Journal of ovarian research · 2016Article
- The endometriotic tissue lining the internal surface of endometrioma: hormonal, genetic, epigenetic status, and gene expression profile.Reproductive sciences (Thousand Oaks, Calif.) · 2015Review
- Hyperbaric oxygenation promotes neural stem cell proliferation and protects the learning and memory ability in neonatal hypoxic-ischemic brain damage.International journal of clinical and experimental pathology · 2015Article
- Estrous cycle-dependent changes of Fas expression in the bovine corpus luteum: influence of keratin 8/18 intermediate filaments and cytokines.Reproductive biology and endocrinology : RB&E · 2012Article
- Apoptosis inducing effect of andrographolide on TD-47 human breast cancer cell line.African journal of traditional, complementary, and alternative medicines : AJTCAM · 2007Article
- Oogenesis in cultures derived from adult human ovaries.Reproductive biology and endocrinology : RB&E · 2005Article
- Oogenesis in adult mammals, including humans: a review.Endocrine · 2005Review
- The novel protein PTPIP51 exhibits tissue- and cell-specific expression.Histochemistry and cell biology · 2005Article
- Origin of germ cells and formation of new primary follicles in adult human ovaries.Reproductive biology and endocrinology : RB&E · 2004Article
- Retinoblastoma (RB1) gene product expression in breast carcinoma. Correlation with Ki-67 growth fraction and biopathological profile.Journal of clinical pathology · 1998Article
- Cytokeratin expression in bovine corpora lutea.Histochemistry and cell biology · 1995Article
- Presence of the intermediate filaments cytokeratins and vimentin in the rat corpus luteum during luteal life-span.Histochemistry and cell biology · 1995Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intermediate filaments (IF) present in the various cells of human ovaries were studied by immunolocalization using antibodies to cytokeratins (CKs), vimentin, desmin and alpha-smooth muscle (alpha-SM) actin. Oocytes revealed a single paranuclear aggregate, which reacted with antibodies to CKs 8, 18 and 19 both in adult and fetal ovaries. The existence of this aggregate was also documented by electron microscopy. Ovarian surface epithelium and granulosa cells consistently coexpressed CKs 8, 18, 19 and vimentin. During follicle maturation vimentin remained unchanged in the granulosa layer while CKs content decreased, showing variation in the amount and distribution of the different CK-types. Thecal cells of secondary and mature follicles showed alpha-SM actin positivity. These contractile fibres increased in mature follicles. Ordinary fibrous stromal cells showed isolated cells which were desmin and alpha-SM actin positive. A similar pattern of IF expression and distribution existed in all stages of development in fetal and embryonic ovaries. These results indicate that CKs are present in human oocytes and that the coexpression of vimentin and CKs can be regarded as a peculiar feature of all ovarian cell types except oocytes and ordinary stromal cells. Contractile properties have been documented associated with a modification in expression of IF proteins. This is likely to represent an integral part of folliculogenesis along with the functional hormone-dependent changes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.