ArticleThe Journal of cell biology1993
Analysis of the sheep trichohyalin gene: potential structural and calcium-binding roles of trichohyalin in the hair follicle.
Article in The Journal of cell biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 72 citations in OpenAlex.
- Transcriptome profile at different physiological stages reveals potential mode for curly fleece in Chinese tan sheep.PloS one · 2013Article
- A pair of transmembrane receptors essential for the retention and pigmentation of hair.Genesis (New York, N.Y. : 2000) · 2012Article
- Common variants in the trichohyalin gene are associated with straight hair in Europeans.American journal of human genetics · 2009Article
- Article
- Sensory ciliogenesis in Caenorhabditis elegans: assignment of IFT components into distinct modules based on transport and phenotypic profiles.Molecular biology of the cell · 2007Article
- EEDA: a protein associated with an early stage of stratified epithelial differentiation.Journal of cellular physiology · 2006Article
- Comparative aspects of the inner root sheath in adult and developing hairs of mammals in relation to the evolution of hairs.Journal of anatomy · 2004Article
- The outer dynein arm-docking complex: composition and characterization of a subunit (oda1) necessary for outer arm assembly.Molecular biology of the cell · 2002Article
- Identification of human epidermal differentiation complex (EDC)-encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library.Genome research · 2001Article
- Expression of a wool intermediate filament keratin transgene in sheep fibre alters structure.Transgenic research · 1998Article
- The Chlamydomonas reinhardtii ODA3 gene encodes a protein of the outer dynein arm docking complex.The Journal of cell biology · 1997Article
- Altered distribution of keratinization markers in epidermolytic hyperkeratosis.Archives of dermatological research · 1995Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trichohyalin is a structural protein that is produced and retained in the cells of the inner root sheath and medulla of the hair follicle. The gene for sheep trichohyalin has been purified and the complete amino acid sequence of trichohyalin determined in an attempt to increase the understanding of the structure and function of this protein in the filamentous network of the hardened inner root sheath cells. Sheep trichohyalin has a molecular weight of 201,172 and is characterized by the presence of a high proportion of glutamate, arginine, glutamine, and leucine residues, together totaling more than 75% of the amino acids. Over 65% of trichohyalin consists of two sets of tandem peptide repeats which are based on two different consensus sequences. Trichohyalin is predicted to form an elongated alpha-helical rod structure but does not contain the sequences required for the formation of intermediate filaments. The amino terminus of trichohyalin contains two EF hand calcium-binding domains indicating that trichohyalin plays more than a structural role within the hair follicle. In situ hybridization studies have shown that trichohyalin is expressed in the epithelia of the tongue, hoof, and rumen as well as in the inner root sheath and medulla of the hair follicle.
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