ArticleAnnals of the rheumatic diseases1993
Giant cells in arthritic synovium.
Article in Annals of the rheumatic diseases, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 34 citations in OpenAlex.
- Characterization of multinucleated giant cells in synovium and subchondral bone in knee osteoarthritis and rheumatoid arthritis.BMC musculoskeletal disorders · 2015Article
- Role of osteoclasts and interleukin-17 in the pathogenesis of rheumatoid arthritis: crucial 'human osteoclastology'.Journal of bone and mineral metabolism · 2012Review
- Role of NADPH oxidase in formation and function of multinucleated giant cells.Journal of innate immunity · 2009Review
- Macrophage-like synoviocytes display phenotypic polymorphisms in a serum-free tissue-culture medium.Rheumatology international · 2006Article
- Persistent expression of mitogenic/transforming factors at the site of failed orthopaedic implants: the impact on immune reactivity.Journal of materials science. Materials in medicine · 1998Article
- Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis.The American journal of pathology · 1998Article
- Is rheumatoid arthritis a failure of B cell death in synovium?Annals of the rheumatic diseases · 1995Review
- Induction of multinucleated giant cells from rheumatoid arthritis (RA) synovial adherent cells by anti-DR antibody.Clinical and experimental immunology · 1994Article
- The nature and origins of synovium: experimental approaches to the study of synoviocyte differentiation.Journal of anatomy · 1994Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesGiant cells are commonly present in inflamed synovium, often in close association with the intimal layer. The nature of these multinucleate cells has been reassessed using new cytochemical and immunochemical techniques.
methodsCryostat sections of non-inflamed, rheumatoid arthritic and osteoarthritic synovia were analysed for the presence of CD68 and non-specific esterase, markers associated with macrophages; activity of uridine diphosphoglucose dehydrogenase, associated with fibroblast-like synoviocytes; and tartrate resistant acid phosphatase and the vitronectin receptor subunit CD51, associated with osteoclasts.
resultsGiant cells were not seen in non-inflamed tissue. In diseased tissue giant cells in the intimal layer fell into two major groups: CD68 negative or dull cells with high uridine diphosphoglucose dehydrogenase (UDPGD) activity suggestive of true synoviocyte polykaryons; and CD68 positive cells with low UDPGD activity suggestive of macrophage polykaryons. The two groups were seen in samples from patients with rheumatoid arthritis (RA) and patients with osteoarthritis (OA), but the former were more prominent in OA and the latter in RA. Most CD68 positive giant cells also showed tartrate resistant acid phosphatase activity and prominent expression of CD51. As such they were histochemically indistinguishable from osteoclasts, but their bone resorbing capacity remains unknown.
conclusionsGiant cells in arthritic synovium appear to be of two types, one related to true synoviocytes and one to macrophages.
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