ArticleCell and tissue research1993
Projections of nitric oxide synthesizing neurons in the guinea-pig colon.
Article in Cell and tissue research, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 99 citations in OpenAlex.
- Morphologies, dimensions and targets of gastric nitric oxide synthase neurons.Cell and tissue research · 2022Article
- Colonic elongation inhibits pellet propulsion and migrating motor complexes in the murine large bowel.The Journal of physiology · 2010Article
- Distribution of P2Y2 receptors in the guinea pig enteric nervous system and its coexistence with P2X2 and P2X3 receptors, neuropeptide Y, nitric oxide synthase and calretinin.Histochemistry and cell biology · 2005Article
- Nitric oxide modulates cholinergic reflex pathways to the longitudinal and circular muscle in the isolated guinea-pig distal colon.The Journal of physiology · 1998Article
- Distribution of NADPH diaphorase-positive neurons in the enteric nervous system of the rabbit intestine.Neurochemical research · 1998Article
- Projections of chemically identified myenteric neurons of the small and large intestine of the mouse.Journal of anatomy · 1997Article
- Ultrastructural localization of NADPH-diaphorase activity in the submucous ganglia of the guinea-pig intestine after vagotomy.Anatomy and embryology · 1996Article
- Distribution of nitric oxide synthase-containing nerves in the aganglionic intestine of mutant rats: a histochemical study.Journal of gastroenterology · 1996Article
- Stimulation-induced 3H-L-citrulline accumulation in isolated longitudinal muscle myenteric plexus preparations of rat small intestine: a measure to characterize nitrergic neurons.Naunyn-Schmiedeberg's archives of pharmacology · 1995Article
- Histochemical methods for detecting nitric oxide synthase.The Histochemical journal · 1995Review
- Histochemistry of nitric oxide synthase in the nervous system.The Histochemical journal · 1995Review
- Origins of nerve fibers containing nitric oxide synthase in the rat celiac-superior mesenteric ganglion.Cell and tissue research · 1995Article
- Projections of neurochemically specified neurons in the porcine colon.Histochemistry and cell biology · 1995Article
- Ultrastructural localisation of NADPH-diaphorase in the chick thymic medulla.Cell and tissue research · 1995Article
- Pharmacological evidence that nitric oxide may be a retrograde messenger in the enteric nervous system.British journal of pharmacology · 1995Article
- Co-localization of nitric oxide synthase and vasoactive intestinal peptide immunoreactivity in neurons of the major pelvic ganglion projecting to the rat rectum and penis.Cell and tissue research · 1994Article
- Evidence for coexistence of ATP and nitric oxide in non-adrenergic, non-cholinergic (NANC) inhibitory neurones in the rat ileum, colon and anococcygeus muscle.Cell and tissue research · 1994Article
- Nitrergic innervation and nitrergic cells in arteriovenous anastomoses.Cell and tissue research · 1994Article
- Nitric oxide synthase in the enteric nervous system of the guinea-pig: a quantitative description.Cell and tissue research · 1994Article
- Nitric oxide synthase in neurons of the gastrointestinal tract of an avian species, Coturnix coturnix.Journal of anatomy · 1994Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The neuronal form of the enzyme nitric oxide synthase, which is an obligatory constituent of neurons that utilise nitric oxide as a transmitter, was revealed histochemically in this study by its ability to transfer a proton from reduced nicotinamide adenine dinucleotide phosphate to nitro-blue tetrazolium. In the guinea-pig colon, nitric oxide synthase was located in numerous irregularly-shaped myenteric neurons with single axons. In the submucosa, a small number of neurons had strong enzyme activity, whereas many were weakly stained. Nerve fibres were found in the longitudinal muscle, circular muscle, muscularis mucosae and ganglia of the two plexuses. No nerve fibres were found in the lamina propria of the mucosa. The same distribution of nerve cells and fibres was revealed using immunohistochemistry for nitric oxide synthase. Lesion studies showed that the axons of myenteric neurons all projected anally. Myenteric cells were the source of nerve fibres in the circular muscle and in more anally located myenteric ganglia. The sparse innervation of submucous ganglia was intrinsic to the submucous plexus. It is suggested that nitric oxide synthase is one of the transmitters of inhibitory neurons to the muscle and is also utilized by descending interneurons of the myenteric plexus.
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