ArticleBritish journal of pharmacology1993
Evaluation of the relaxant effects of SCA40, a novel charybdotoxin-sensitive potassium channel opener, in guinea-pig isolated trachealis.
Article in British journal of pharmacology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 67 citations in OpenAlex.
- Mediation of mammalian olfactory response by presence of odor-evoked potassium current.Frontiers in allergy · 2024Article
- Effects of potassium channel modulators on the responses of mammalian slowly adapting mechanoreceptors.IBRO neuroscience reports · 2022Article
- Membrane-Facilitated Receptor Access and Binding Mechanisms of Long-ActingMolecular pharmacology · 2021Article
- Calcium and potassium channels are involved in curcumin relaxant effect on tracheal smooth muscles.Pharmaceutical biology · 2020Article
- The Relaxant Effect of Crocin on Rat Tracheal Smooth Muscle and Its Possible Mechanisms.Iranian journal of pharmaceutical research : IJPR · 2019Article
- Relaxant effect of Curcuma longa on rat tracheal smooth muscle and its possible mechanisms.Pharmaceutical biology · 2017Article
- Pharmacological characterisation of the interaction between glycopyrronium bromide and indacaterol fumarate in human isolated bronchi, small airways and bronchial epithelial cells.Respiratory research · 2016Article
- Evaluation of the Bronchorelaxant, Genotoxic, and Antigenotoxic Effects of Cassia alata L.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Activation of large conductance potassium channels inhibits the afferent and efferent function of airway sensory nerves in the guinea pig.The Journal of clinical investigation · 1997Article
- Effects of SCA40 on human isolated bronchus and human polymorphonuclear leukocytes: comparison with rolipram, SKF94120 and levcromakalim.British journal of pharmacology · 1996Article
- High-conductance calcium-activated potassium channels; structure, pharmacology, and function.Journal of bioenergetics and biomembranes · 1996Review
- Effects of some K(+)-channel inhibitors on the electrical behaviour of guinea-pig isolated trachealis and on its responses to spasmogenic drugs.British journal of pharmacology · 1996Article
- A comparison of the effects of SCA40, NS 004 and NS 1619 on large conductance Ca(2+)-activated K+ channels in bovine tracheal smooth muscle cells in culture.British journal of pharmacology · 1995Article
- Evidence that BKCa channel activation contributes to K+ channel opener induced relaxation of the porcine coronary artery.Naunyn-Schmiedeberg's archives of pharmacology · 1995Article
- Pharmacology of the potassium channel openers.Cardiovascular drugs and therapy · 1995Review
- Further analysis of the mechanisms underlying the tracheal relaxant action of SCA40.British journal of pharmacology · 1995Article
- Cardiovascular effects of SCA40, a novel potassium channel opener, in rats.British journal of pharmacology · 1993Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Experiments have been performed in order to analyse the mechanism whereby SCA40, a new imidazo[1,2-a]pyrazine derivative relaxes airway smooth muscle. 2. SCA40 (0.01-10 microM) caused a complete and concentration-dependent relaxation of guinea-pig isolated trachea contracted with 20 mM KCl but failed to inhibit completely the spasmogenic effects of 80 mM KCl. 3. Quinine (30 microM) antagonized the relaxant activity of SCA40 in 20 mM KCl-contracted guinea-pig isolated trachea. The ATP-sensitive K(+)-channel blocker, glibenclamide (3 microM), did not antagonize the relaxant activity of SCA40 in either 20 mM KCl or 1 microM carbachol-contracted isolated trachea. 4. SCA40 (0.01-10 microM) and isoprenaline (0.1 nM-10 microM) caused a complete and concentration-dependent relaxation of guinea-pig isolated trachea contracted with carbachol 1 microM. 5. The large-conductance Ca(2+)-activated K(+)-channel blocker, charybdotoxin (60-180 nM), non-competitively antagonized the relaxant activity of isoprenaline on 1 microM carbachol-contracted trachea. The inhibition was characterized by rightward shifts of the isoprenaline concentration-relaxation curves with depression of their maxima. 6. The relaxant activity of SCA40 in 1 microM carbachol-contracted trachea was antagonized by charybdotoxin (60-600 nM) in an apparently competitive manner. The concentration-relaxation curves to SCA40 were shifted to the right with no significant alteration in the maximum response. 7. It is concluded that SCA40 is a novel potassium channel opener which is a potent relaxant of guinea-pig airway smooth muscle in vitro. The relaxant activity of SCA40 does not involve ATP-sensitive K+-channels but rather large-conductance Ca2'-activated K+-channels or other charybdotoxin sensitive K+-channels.
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