ArticleProceedings of the National Academy of Sciences of the United States of America1993
Granulocyte-macrophage and macrophage colony-stimulating factors differentially regulate alpha v integrin expression on cultured human macrophages.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 106 citations in OpenAlex.
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- Biophysical regulation of macrophages in health and disease.Journal of leukocyte biology · 2019Review
- Alterations of tumor microenvironment by nitric oxide impedes castration-resistant prostate cancer growth.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- RGD-Modified Albumin Nanoconjugates for Targeted Delivery of a Porphyrin Photosensitizer.Molecular pharmaceutics · 2017Article
- Characterization of early neovascular response to acute lung ischemia using simultaneous (19)F/ (1)H MR molecular imaging.Angiogenesis · 2014Article
- Circulating Porphyromonas gingivalis lipopolysaccharide resets cardiac homeostasis in mice through a matrix metalloproteinase-9-dependent mechanism.Physiological reports · 2013Article
- Molecular MR imaging of neovascular progression in the Vx2 tumor with αvβ3-targeted paramagnetic nanoparticles.Radiology · 2013Article
- Interleukin-33 upregulation in peripheral leukocytes and CNS of multiple sclerosis patients.Clinical immunology (Orlando, Fla.) · 2012Article
- Molecular photoacoustic imaging of angiogenesis with integrin-targeted gold nanobeacons.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2011Article
- MR angiogenesis imaging with Robo4- vs. alphaVbeta3-targeted nanoparticles in a B16/F10 mouse melanoma model.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- The formin FRL1 (FMNL1) is an essential component of macrophage podosomes.Cytoskeleton (Hoboken, N.J.) · 2010Article
- Angiogenesis imaging with vascular-constrained particles: the why and how.European journal of nuclear medicine and molecular imaging · 2010Review
- MR molecular imaging of aortic angiogenesis.JACC. Cardiovascular imaging · 2010Article
- Theragnostics for tumor and plaque angiogenesis with perfluorocarbon nanoemulsions.Angiogenesis · 2010Review
- Nanomedicine strategies for molecular targets with MRI and optical imaging.Future medicinal chemistry · 2010Review
- Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotype.Laboratory investigation; a journal of technical methods and pathology · 2009Article
- High sensitivity: high-resolution SPECT-CT/MR molecular imaging of angiogenesis in the Vx2 model.Investigative radiology · 2009Article
- The angiogenic response is dictated by beta3 integrin on bone marrow-derived cells.The Journal of cell biology · 2008Article
- Antiangiogenic synergism of integrin-targeted fumagillin nanoparticles and atorvastatin in atherosclerosis.JACC. Cardiovascular imaging · 2008Article
- Minute dosages of alpha(nu)beta3-targeted fumagillin nanoparticles impair Vx-2 tumor angiogenesis and development in rabbits.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The colony-stimulating factors (CSFs) greatly influence mature macrophage function in vitro: macrophage (M)-CSF induces maturation of monocytes and enhances differentiated cell function; granulocyte-macrophage (GM)-CSF stimulates a variety of antimicrobial functions. In vivo M-CSF is thought to promote differentiation, and GM-CSF is thought to potentiate the inflammatory response. One mechanism by which these differential effects may be achieved is through the receptor-mediated interaction of macrophages with their extracellular matrix. Here we show that M-CSF induces specifically the expression of the alpha v beta 5 integrin receptor, whereas GM-CSF rapidly induces mRNA and surface expression of the alpha v beta 3 integrin. The M-CSF-treated cells acquire a flattened epitheloid phenotype, and on vitronectin the alpha v beta 5 is located in adhesion plaques. These cells do not bind collagen or laminin. In contrast, cells treated with GM-CSF adopt an elongated phenotype on a number of substrates, including collagen and laminin, and express alpha v beta 3 at the leading edge of cells on vitronectin. These results suggest that a primary means by which the CSFs exert their individual effects on mature cells may be through regulating integrin expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.