ArticleProceedings of the National Academy of Sciences of the United States of America1993
Identification of a direct interaction between interleukin 2 and the p64 interleukin 2 receptor gamma chain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 74 citations in OpenAlex.
- STAT5 Is Necessary for the Metabolic Switch Induced by IL-2 in Cervical Cancer Cell Line SiHa.International journal of molecular sciences · 2024Article
- Modeling cell-specific dynamics and regulation of the common gamma chain cytokines.Cell reports · 2021Article
- Elucidating the Pivotal Immunomodulatory and Anti-Inflammatory Potentials of Chloroquine and Hydroxychloroquine.Journal of immunology research · 2020Review
- Pleiotropic Effects of IL-2 on Cancer: Its Role in Cervical Cancer.Mediators of inflammation · 2016Review
- The common γ-chain cytokine receptor: tricks-and-treats for T cells.Cellular and molecular life sciences : CMLS · 2016Review
- Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Characterisation and expression analysis of interleukin 2 (IL-2) and IL-21 homologues in the Japanese pufferfish, Fugu rubripes, following their discovery by synteny.Immunogenetics · 2005Article
- Involvement of the ubiquitin/proteasome system in sorting of the interleukin 2 receptor beta chain to late endocytic compartments.Molecular biology of the cell · 2001Article
- The first alpha helix of interleukin (IL)-2 folds as a homotetramer, acts as an agonist of the IL-2 receptor beta chain, and induces lymphokine-activated killer cells.The Journal of experimental medicine · 2000Article
- Solution assembly of the pseudo-high affinity and intermediate affinity interleukin-2 receptor complexes.Protein science : a publication of the Protein Society · 1999Article
- Preassembly of interleukin 2 (IL-2) receptor subunits on resting Kit 225 K6 T cells and their modulation by IL-2, IL-7, and IL-15: a fluorescence resonance energy transfer study.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Article
- An alpha-helical signal in the cytosolic domain of the interleukin 2 receptor beta chain mediates sorting towards degradation after endocytosis.The Journal of cell biology · 1997Article
- Kinetic analysis of ligand binding to interleukin-2 receptor complexes created on an optical biosensor surface.Protein science : a publication of the Protein Society · 1996Article
- Elf-1 and Stat5 bind to a critical element in a new enhancer of the human interleukin-2 receptor alpha gene.Molecular and cellular biology · 1996Article
- Molecular mechanisms regulating the hyaluronan binding activity of the adhesion protein CD44.Journal of neuro-oncology · 1995Article
- Chloroquine inhibits T cell proliferation by interfering with IL-2 production and responsiveness.Clinical and experimental immunology · 1995Article
- Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Homology model of human interferon-alpha 8 and its receptor complex.Protein science : a publication of the Protein Society · 1995Article
- Endocytosis of interleukin 2 receptors in human T lymphocytes: distinct intracellular localization and fate of the receptor alpha, beta, and gamma chains.The Journal of cell biology · 1995Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The interleukin 2 receptor (IL-2R) consists of at least two subunits, alpha and beta, both of which can bind interleukin 2 (IL-2). Recent studies have demonstrated the existence of a third subunit, a 64-kDa molecule termed IL-2R gamma chain, and have suggested that gamma chain functions to regulate the rate of IL-2 dissociation from the receptor. In the present report we have addressed whether the gamma chain modulates IL-2R affinity by contributing contact sites for IL-2 binding. Using reagents that allow the IL-2R complex to be immunoprecipitated through the IL-2 molecule itself, we demonstrate the existence of a stable IL-2-IL-2R gamma-chain complex. These studies thus establish that the IL-2R gamma chain directly contributes to the IL-2-binding site, consistent with the hypothesis that gamma chain influences IL-2R affinity through its direct interaction with IL-2.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.