ArticleMolecular and cellular biology1993
Distinct regions of the human granulocyte-colony-stimulating factor receptor cytoplasmic domain are required for proliferation and gene induction.
Article in Molecular and cellular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 130 citations in OpenAlex.
- Selective activation of STAT3 and STAT5 dictates the fate of myeloid progenitor cells.Cell death discovery · 2023Article
- Gain-of-function mutations in granulocyte colony-stimulating factor receptor (CSF3R) reveal distinct mechanisms of CSF3R activation.The Journal of biological chemistry · 2018Article
- Severe congenital neutropenias.Nature reviews. Disease primers · 2017Review
- The importance of the granulocyte-colony stimulating factor in oncology.Clujul medical (1957) · 2015Review
- Establishment of cancer cell lines from rat hepatocholangiocarcinoma and assessment of the role of granulocyte-colony stimulating factor and hepatocyte growth factor in their growth, motility and survival.Journal of hepatology · 2009Article
- Granulocyte colony-stimulating factor: molecular mechanisms of action during steady state and 'emergency' hematopoiesis.Cytokine · 2008Review
- A novel mutation in the juxtamembrane intracellular sequence of the granulocyte colony-stimulating factor (G-CSF) receptor gene in a patient with severe congenital neutropenia augments GCSF proliferation activity but not through the MAP kinase cascade.International journal of hematology · 2005Article
- Involvement of Shc and Cbl-PI 3-kinase in Lyn-dependent proliferative signaling pathways for G-CSF.Oncogene · 2000Article
- Increased granulocyte colony-stimulating factor responsiveness but normal resting granulopoiesis in mice carrying a targeted granulocyte colony-stimulating factor receptor mutation derived from a patient with severe congenital neutropenia.The Journal of clinical investigation · 1998Article
- Cytoplasmic domains of the common beta-chain of the GM-CSF/IL-3/IL-5 receptors that are required for inducing differentiation or clonal suppression in myeloid leukaemic cell lines.The EMBO journal · 1997Article
- The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Activating mechanism of CNTF and related cytokines.Molecular neurobiology · 1996Review
- Functional regions of the mouse thrombopoietin receptor cytoplasmic domain: evidence for a critical region which is involved in differentiation and can be complemented by erythropoietin.Molecular and cellular biology · 1996Article
- Differentiation and growth arrest signals are generated through the cytoplasmic region of gp130 that is essential for Stat3 activation.The EMBO journal · 1996Article
- IL-6 cytokine family and signal transduction: a model of the cytokine system.Journal of molecular medicine (Berlin, Germany) · 1996Review
- Distinct signal transduction through the tyrosine-containing domains of the granulocyte colony-stimulating factor receptor.The EMBO journal · 1995Article
- Activating point mutations in the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors suggest the involvement of beta subunit dimerization and cell type-specific molecules in signalling.The EMBO journal · 1995Article
- Erythropoietin-induced cellular differentiation requires prolongation of the G1 phase of the cell cycle.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Characterization of mpl cytoplasmic domain sequences required for myeloproliferative leukemia virus pathogenicity.Journal of virology · 1994Article
- Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Using two different cell systems, we show that the cytoplasmic domain of the granulocyte-colony-stimulating factor receptor (G-CSFR) may be composed of at least two functional regions. The first, within the membrane-proximal 57 amino acids, is absolutely required to deliver a proliferative signal. This region contains two sequence motifs conserved between members of the hematopoietin receptor family. The second functional region resides between amino acids 57 and 96. This region is required for the induction of acute-phase plasma protein gene expression when the G-CSFR is transfected into human hepatoma cell lines. The G-CSFR-transfected hepatoma cells respond to G-CSF by increasing the production of the same set of plasma proteins as stimulated by interleukin-6, suggesting that the two cytokines share a common signal transduction pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.