ArticleThe Journal of clinical investigation1993
Neonatal hypothyroidism affects the timely expression of myelin-associated glycoprotein in the rat brain.
Article in The Journal of clinical investigation, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 165 citations in OpenAlex.
- Oral Intake of Plasticizer Di-(2-ethylhexyl) Phthalate Disrupts Cerebellar Myelination via Thyroid Signaling in Aging Mice.Environment & health (Washington, D.C.) · 2025Article
- The Role of Thyroid Hormones in Neurodegenerative Disorders: Opportunities and Challenges.Molecular neurobiology · 2025Review
- Review
- Investigating the Predictive Value of Thyroid Hormone Levels for Stroke Prognosis.Neurology international · 2023Review
- Nuclear hormone receptors in demyelinating diseases.Journal of neuroendocrinology · 2022Review
- Pathophysiology and Clinical Features of Neuropsychiatric Manifestations of Thyroid Disease.Journal of the Endocrine Society · 2022Review
- Human Oligodendrocytes and Myelin In Vitro to Evaluate Developmental Neurotoxicity.International journal of molecular sciences · 2021Review
- Rabbit neurospheres as a novel in vitro tool for studying neurodevelopmental effects induced by intrauterine growth restriction.Stem cells translational medicine · 2021Article
- Transient Hypothyroidism During Lactation Alters the Development of the Corpus Callosum in Rats. AnFrontiers in neuroanatomy · 2020Article
- Monocarboxylate Transporter 8 Deficiency: Delayed or Permanent Hypomyelination?Frontiers in endocrinology · 2020Review
- Transient Hypothyroidism During Lactation Arrests Myelination in the Anterior Commissure of Rats. A Magnetic Resonance Image and Electron Microscope Study.Frontiers in neuroanatomy · 2018Article
- GC-1: A Thyromimetic With Multiple Therapeutic Applications in Liver Disease.Gene expression · 2017Review
- BDE-99 impairs differentiation of human and mouse NPCs into the oligodendroglial lineage by species-specific modes of action.Scientific reports · 2017Article
- Influence of maternal thyroid hormones during gestation on fetal brain development.Neuroscience · 2017Review
- Individualized treatment to optimize eventual cognitive outcome in congenital hypothyroidism.Pediatric research · 2016Article
- Thyroid Hormone Signaling in Oligodendrocytes: from Extracellular Transport to Intracellular Signal.Molecular neurobiology · 2016Review
- Sialic Acid Is Required for Neuronal Inhibition by Soluble MAG but not for Membrane Bound MAG.Frontiers in molecular neuroscience · 2016Article
- Systematic Review of Pharmacological Properties of the Oligodendrocyte Lineage.Frontiers in cellular neuroscience · 2016Review
- Thyroid hormone alleviates demyelination induced by cuprizone through its role in remyelination during the remission period.Experimental biology and medicine (Maywood, N.J.) · 2015Article
- Mutations of the thyroid hormone transporter MCT8 cause prenatal brain damage and persistent hypomyelination.The Journal of clinical endocrinology and metabolism · 2014Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Congenital hypothyroidism strongly affects myelination. To assess the role of thyroid hormone on myelin gene expression, we have studied the effect of hypothyroidism on the steady state levels of myelin-associated glycoprotein (MAG) and its mRNA in rat brain during the first postnatal month. As studied by immunoblot analysis of several brain regions, MAG increased from days 10-15 onwards, reaching constant levels by days 20-25. Hypothyroid samples showed a delay in the accumulation of MAG that was more severe in rostral regions, such as cortex and hippocampus. The effect of hypothyroidism on the accumulation of the protein correlated with mRNA levels. MAG mRNA started to accumulate in the cerebrum of normal animals by postnatal day 7, reaching maximal levels by day 20. Hypothyroid rats showed a delay of several days in the onset of mRNA expression, increasing thereafter at the same rate as in normal animals, and eventually reaching similar values. When individual brain regions were analyzed, we found strong regional differences in the effect of hypothyroidism. The cerebral cortex was most affected, with messenger levels lower than in normal animals at all ages. In more caudal regions differences between control and hypothyroid rats were evident only at the earlier stages of myelination, with spontaneous recovery at later ages. By run on analysis, we found no differences in transcriptional activities of the MAG gene in normal, hypothyroid, or T4-treated rats. Therefore, the effects of hypothyroidism on MAG mRNA and protein levels were most likely caused by decreased mRNA stability. We propose that thyroid hormone contributes to enhanced myelin gene expression by affecting the stability of newly transcribed mRNA in the early phases of myelination.
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