ArticleAnnals of the rheumatic diseases1993
Localisation of vitronectin receptor immunoreactivity and tartrate resistant acid phosphatase activity in synovium from patients with inflammatory or degenerative arthritis.
Article in Annals of the rheumatic diseases, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 32 citations in OpenAlex.
- Dysregulated integrin αVβ3 and CD47 signaling promotes joint inflammation, cartilage breakdown, and progression of osteoarthritis.JCI insight · 2019Article
- Article
- Characterization of multinucleated giant cells in synovium and subchondral bone in knee osteoarthritis and rheumatoid arthritis.BMC musculoskeletal disorders · 2015Article
- Improving oral implant osseointegration in a murine model via Wnt signal amplification.Journal of clinical periodontology · 2014Article
- Article
- Mechanisms of bone loss in inflammatory arthritis: diagnosis and therapeutic implications.Arthritis research · 2000Review
- The vitronectin receptor and its associated CD47 molecule mediates proinflammatory cytokine synthesis in human monocytes by interaction with soluble CD23.The Journal of cell biology · 1999Article
- Decreased angiogenesis and arthritic disease in rabbits treated with an alphavbeta3 antagonist.The Journal of clinical investigation · 1999Article
- Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis.The American journal of pathology · 1998Article
- The vitronectin receptor (alpha V beta 3) as an example for the role of integrins in T lymphocyte stimulation.Immunologic research · 1996Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The influx of cells into the synovial intima in rheumatoid joints may include osteoclasts and their precursors. The distribution of osteoclast markers--namely, tartrate resistant acid phosphatase activity and the expression of vitronectin receptor (shown with monoclonal antibodies 13C2 and 23C6)--was therefore examined in synovium obtained from patients with rheumatoid (RA) or degenerative (OA) arthritis. Tartrate resistant acid phosphatase positive cells were found in frozen sections of 60% (n = 30) of RA and 69% (n = 29) of OA synovial membranes. Whereas all synovia tested (four RA, four OA) showed diffuse staining of the lining cells with 13C2, 55% (n = 11) of RA and 57% (n = 14) of OA synovial membranes contained isolated cells stained with 23C6 scattered throughout the tissue. In cultures of synovial cells, tartrate resistant acid phosphatase positive, multinuclear, and 23C6 positive cells were found; these cells did not, however, form resorption pits on bone slices. The results show that fully differentiated osteoclasts are uncommon in synovium from patients with either degenerative or inflammatory arthropathies.
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