ArticleProceedings of the National Academy of Sciences of the United States of America1993
ARIA, a protein that stimulates acetylcholine receptor synthesis, also induces tyrosine phosphorylation of a 185-kDa muscle transmembrane protein.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 76 citations in OpenAlex.
- Identification of gene transcripts expressed by postsynaptic neurons during synapse formation encoding cell surface proteins with presumptive synaptogenic activity.Synapse (New York, N.Y.) · 2010Article
- Neurotrophins induce neuregulin release through protein kinase Cdelta activation.The Journal of biological chemistry · 2009Article
- Neuregulin-1: a potential endogenous protector in perinatal brain white matter damage.Neonatology · 2008Review
- Endogenous neuregulin restores radial glia in a (ferret) model of cortical dysplasia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Neuregulins rescue PC12-ErbB-4 cells from cell death induced by beta-amyloid peptide: involvement of PI3K and PKC.Journal of molecular neuroscience : MN · 2005Article
- Neuregulin induces sustained reactive oxygen species generation to mediate neuronal differentiation.Cellular and molecular neurobiology · 2001Article
- Neuregulin induces GABA(A) receptor subunit expression and neurite outgrowth in cerebellar granule cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Biologic effects of heregulin/neu differentiation factor on normal and malignant human breast and ovarian epithelial cells.Oncogene · 1999Article
- Essential roles of c-JUN and c-JUN N-terminal kinase (JNK) in neuregulin-increased expression of the acetylcholine receptor epsilon-subunit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Agrin can mediate acetylcholine receptor gene expression in muscle by aggregation of muscle-derived neuregulins.The Journal of cell biology · 1998Article
- Intercellular communication that mediates formation of the neuromuscular junction.Molecular neurobiology · 1997Review
- Neuregulins stimulate the functional expression of Ca2+-activated K+ channels in developing chicken parasympathetic neurons.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Induction by agrin of ectopic and functional postsynaptic-like membrane in innervated muscle.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- The cellular response to neuregulins is governed by complex interactions of the erbB receptor family.Molecular and cellular biology · 1995Article
- ARIA is concentrated in the synaptic basal lamina of the developing chick neuromuscular junction.The Journal of cell biology · 1995Article
- ErbB3 and ErbB2/neu mediate the effect of heregulin on acetylcholine receptor gene expression in muscle: differential expression at the endplate.The EMBO journal · 1995Article
- ARIA can be released from extracellular matrix through cleavage of a heparin-binding domain.The Journal of cell biology · 1995Article
- A role for the acetylcholine receptor-inducing protein ARIA in oligodendrocyte development.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Developmental neurobiology. Recitative and aria.Nature · 1993Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Motoneurons promote the accumulation of acetylcholine receptors (AChRs) at developing neuromuscular synapses. The AChR-inducing activity protein ARIA, which is purified from chicken brain and increases the synthesis of AChRs in chicken myotubes, may play a crucial role in this process. Here we show that ARIA induces the rapid tyrosine phosphorylation of a M(r) 185,000 protein (p185) in muscle cells. Phosphorylation of p185 correlates with AChR induction at each stage of ARIA purification. Moreover, medium conditioned by spinal cord motoneurons stimulates AChR synthesis and p185 phosphorylation. Studies with membrane-impermeant reagents and 125I-labeled ARIA indicate that p185 is a transmembrane ARIA-receptor tyrosine kinase. Our data suggests that muscle AChR synthesis can be regulated through tyrosine phosphorylation.
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