ArticleThe EMBO journal1993
A putative zinc-binding protein on lampbrush chromosome loops.
Article in The EMBO journal, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 90 citations in OpenAlex.
- Imaging the dynamics of transcription loops in living chromosomes.Chromosoma · 2018Article
- A role for SOX9 in post-transcriptional processes: insights from the amphibian oocyte.Scientific reports · 2018Article
- The tripartite motif of nuclear factor 7 is required for its association with transcriptional units.Molecular and cellular biology · 2007Article
- Localized co-transcriptional recruitment of the multifunctional RNA-binding protein CELF1 by lampbrush chromosome transcription units.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2007Article
- Distribution of XCAP-E and XCAP-D2 in the Xenopus oocyte nucleus.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2003Article
- Lampbrush chromosomes and associated bodies: new insights into principles of nuclear structure and function.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2002Review
- PML protein isoforms and the RBCC/TRIM motif.Oncogene · 2001Review
- The RING finger/B-box factor TAM-1 and a retinoblastoma-like protein LIN-35 modulate context-dependent gene silencing in Caenorhabditis elegans.Genes & development · 1999Article
- HERF1, a novel hematopoiesis-specific RING finger protein, is required for terminal differentiation of erythroid cells.Molecular and cellular biology · 1999Article
- Localization of nascent RNA and CREB binding protein with the PML-containing nuclear body.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- mof, a putative acetyl transferase gene related to the Tip60 and MOZ human genes and to the SAS genes of yeast, is required for dosage compensation in Drosophila.The EMBO journal · 1997Article
- Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1.Nucleic acids research · 1996Article
- A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors.The EMBO journal · 1996Article
- Structural organization and mammary-specific expression of the butyrophilin gene.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
- Finely tuned regulation of cytoplasmic retention of Xenopus nuclear factor 7 by phosphorylation of individual threonine residues.Molecular and cellular biology · 1996Article
- In vivo and in vitro characterization of the B1 and B2 zinc-binding domains from the acute promyelocytic leukemia protooncoprotein PML.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- New testis-specific expressed genes on mouse Chromosome 11.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
- A monoclonal antibody against DNA topoisomerase II labels the axial granules of Pleurodeles lampbrush chromosomes.Chromosoma · 1996Article
- Novel topology of a zinc-binding domain from a protein involved in regulating early Xenopus development.The EMBO journal · 1995Article
- A zinc-binding domain is required for targeting the maternal nuclear protein PwA33 to lampbrush chromosome loops.The Journal of cell biology · 1995Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We used mAb A33/22, which recognizes a nuclear protein on the loops of amphibian lampbrush chromosomes, to select cDNA clone PwA33 from an expression library of the newt Pleurodeles waltl. A myc-tagged transcript of clone PwA33 was injected into Pleurodeles oocytes. The translation product localized in the germinal vesicle (GV) and was distributed on the lampbrush loops in a pattern identical to that of the endogenous protein. PwA33 encodes a 71 kDa protein with three distinct domains: a region rich in Cys/His residues that may form zinc fingers, a coiled-coil domain with potential for dimerization and a third 'rfp-like' domain that is shared by several other nuclear proteins. The putative zinc fingers and the coiled-coil domain resemble features in known nucleic acid-binding regulatory proteins. These structures, coupled with a distinctive pattern of expression in embryonic tissues, suggest that A33 may function as a regulatory protein during early development. It is unlikely that the large store of A33 in the GV is bound to DNA. Instead, its association with the nascent transcripts on the lampbrush chromosome loops suggests a role in pre-mRNA synthesis or processing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.