ArticleClinical and experimental immunology1993
Complement activation in septic baboons detected by neoepitope-specific assays for C3b/iC3b/C3c, C5a and the terminal C5b-9 complement complex (TCC).
Article in Clinical and experimental immunology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Inhibition of Alternative and Terminal Complement Pathway Components Modulate the Immune Response Against Bacteria and Fungi in Whole Blood.Scandinavian journal of immunology · 2025Article
- The neoepitope of the complement C5b-9 Membrane Attack Complex is formed by proximity of adjacent ancillary regions of C9.Communications biology · 2023Article
- C5a elevation in convalescents from severe COVID-19 is not associated with early complement activation markers C3bBbP or C4d.Frontiers in immunology · 2022Article
- Air Bubbles Activate Complement and Trigger Hemostasis and C3-Dependent Cytokine Release Ex Vivo in Human Whole Blood.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- A porcine model of hemodialyzer reactions: roles of complement activation and rinsing back of extracorporeal blood.Renal failure · 2021Article
- Elevated Terminal C5b-9 Complement Complex 10 Weeks Post Kidney Transplantation Was Associated With Reduced Long-Term Patient and Kidney Graft Survival.Frontiers in immunology · 2021Article
- Sarcolemmal Complement Membrane Attack Complex Deposits During Acute Rejection of Myofibers in Nonhuman Primates.Journal of neuropathology and experimental neurology · 2019Article
- Alginate microbeads are coagulation compatible, while alginate microcapsules activate coagulation secondary to complement or directly through FXII.Acta biomaterialia · 2017Article
- Iron oxide nanoparticles induce cytokine secretion in a complement-dependent manner in a human whole blood model.International journal of nanomedicine · 2017Article
- The key roles of complement and tissue factor in Escherichia coli-induced coagulation in human whole blood.Clinical and experimental immunology · 2015Article
- The anti-inflammatory effect of combined complement and CD14 inhibition is preserved during escalating bacterial load.Clinical and experimental immunology · 2015Article
- Post challenge inhibition of C3 and CD14 attenuates Escherichia coli-induced inflammation in human whole blood.Innate immunity · 2014Article
- C1-inhibitor efficiently inhibits Escherichia coli-induced tissue factor mRNA up-regulation, monocyte tissue factor expression and coagulation activation in human whole blood.Clinical and experimental immunology · 2013Article
- Bacillus anthracis peptidoglycan activates human platelets through FcγRII and complement.Blood · 2013Article
- The role of properdin in zymosan- and Escherichia coli-induced complement activation.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Intramedullary nailing of femoral shaft fractures in polytraumatized patients. a longitudinal, prospective and observational study of the procedure-related impact on cardiopulmonary- and inflammatory responses.Scandinavian journal of trauma, resuscitation and emergency medicine · 2012Article
- The role of complement system in septic shock.Clinical & developmental immunology · 2012Review
- Alteration of complement hemolytic activity in different trauma and sepsis models.Journal of inflammation research · 2012Article
- Ornithodoros moubata complement inhibitor is an equally effective C5 inhibitor in pigs and humans.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
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10 authors.
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Abstract
We have investigated the cross-reactivity of various species in neoepitope-specific methods for quantification of human complement activation products. In contrast to most other species examined, baboon showed a substantial cross-reactivity supporting a high degree of homology between human and baboon complement. An assay for C3b, iC3b and C3c (MoAb bH6) showed moderately good reactivity, in contrast to a C3a assay which did not cross-react. Excellent reactivity was found for C5a using MoAbs C17/5 and G25/2. The reactivity of an established TCC assay (MoAb aE11 to a C9 neoepitope and polyclonal antibody to C5) was improved substantially by replacing the anti-C5 antibody with a new MoAb to C6 particularly selected on the basis of baboon cross-reactivity. Plasma samples from baboons receiving 2.5 x 10(9) and 1.0 x 10(10) live Escherichia coli bacteria/kg were examined with the assays described. In vivo complement activation with the lowest dose was moderate and kept under control, in contrast to the highest dose, where an uncontrolled increase in all activation products continued throughout the infusion period. These results support the hypothesis that sufficiently high amounts of endotoxin lead to uncontrolled activation of complement as seen in irreversible septic shock. The results are discussed with particular emphasis on activation of the terminal complement pathway.
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