ArticleImmunogenetics1993
Different rates of HLA class I molecule assembly which are determined by amino acid sequence in the alpha 2 domain.
Article in Immunogenetics, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 46 citations in OpenAlex.
- Genetics of ankylosing spondylitis--insights into pathogenesis.Nature reviews. Rheumatology · 2016Review
- Distinct assembly profiles of HLA-B molecules.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- The multiple immune-evasion genes of murine cytomegalovirus are not redundant: m4 and m152 inhibit antigen presentation in a complementary and cooperative fashion.The Journal of experimental medicine · 2001Article
- Predisposing factors in the spondyloarthropathies: new insights into the role of HLA-B27.Current rheumatology reports · 2001Review
- T cell receptor usage in infectious disease.Springer seminars in immunopathology · 1999Review
- Human cytomegalovirus US2 destabilizes major histocompatibility complex class I heavy chains.Journal of virology · 1997Article
- Human cytomegalovirus US3 impairs transport and maturation of major histocompatibility complex class I heavy chains.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- LMP-associated proteolytic activities and TAP-dependent peptide transport for class 1 MHC molecules are suppressed in cell lines transformed by the highly oncogenic adenovirus 12.The Journal of experimental medicine · 1996Article
- Binding of nonamer peptides to three HLA-B51 molecules which differ by a single amino acid substitution in the A-pocket.Immunogenetics · 1996Article
- Low HLA-C expression at cell surfaces correlates with increased turnover of heavy chain mRNA.The Journal of experimental medicine · 1995Article
- Species-specific differences in chaperone interaction of human and mouse major histocompatibility complex class I molecules.The Journal of experimental medicine · 1995Article
- Down-regulation of major histocompatibility complex class I synthesis by murine cytomegalovirus early gene expression.Journal of virology · 1994Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Assembly of HLA class I molecules was studied using pulse-chase labeling of B-lymphoblastoid cell lines with 35S-methionine, immunoprecipitation with antibodies detecting free or beta 2-microglobulin-associated heavy chain and isoelectric focusing. Marked differences between the products of different class I alleles were noted. HLA-B51 assembled very inefficiently, with considerable free heavy chain still detected in an unsialated form after a four hour chase. The closely related molecule HLA-B35 was in contrast rapidly assembled, all newly synthesized heavy chain being detected in a beta 2m-associated sialated form within 30 minutes. Analysis of naturally occurring variants related to HLA-B35 and HLA-B51 localized the region determining assembly efficiency to the alpha 2 domain, in which these molecules differ at eight amino acid residues. The effect was not due to a linked dominant gene, as both patterns of assembly were observed in a single cell line.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.