ArticleProceedings of the National Academy of Sciences of the United States of America1993
The mouse intracisternal A particle-promoted placental gene retrotransposition is mouse-strain-specific.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 24 citations in OpenAlex.
- Transposable elements and viruses as factors in adaptation and evolution: an expansion and strengthening of the TE-Thrust hypothesis.Ecology and evolution · 2012Article
- Retrotransposon-centered analysis of piRNA targeting shows a shift from active to passive retrotransposon transcription in developing mouse testes.BMC genomics · 2011Article
- Microarray-based global mapping of integration sites for the retrotransposon, intracisternal A-particle, in the mouse genome.Nucleic acids research · 2008Article
- DNA methylation in placentas of interspecies mouse hybrids.Genetics · 2003Article
- Cloning and characterization of ectopically expressed transcripts for the actin-binding protein MIPP in mouse mammary carcinomas.Oncogene · 2001Article
- Use of a mammalian interspersed repetitive (MIR) element in the coding and processing sequences of mammalian genes.Nucleic acids research · 1995Article
- PANG, a gene encoding a neuronal glycoprotein, is ectopically activated by intracisternal A-type particle long terminal repeats in murine plasmacytomas.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insertion of a single long terminal repeat (LTR) of an intracisternal A particle (IAP) gene into a placenta-expressed cellular gene (mouse IAP-promoted placental gene, MIPP) has recently been found for the mouse strains Swiss and CF-1. To test whether such a retrotransposition event has also taken place in other strains of mouse, genomic DNA and total RNAs were analyzed from the outbred CF-1 strain and five inbred strains of mouse, AKR/J, C57BL/6J, DBA/2J, C3H/HeJ, and BALB/c. Specific DNA fragments flanking the LTR region were isolated from MIPP cDNA and genomic clones and used as hybridization probes. Three transcripts [two minor, 4.4 kilobases (kb) and 2.2 kb; one major, 1.2 kb] were detected. The 4.4-kb and 2.2-kb species were found in all strains of mouse studied. The 1.2-kb transcript (promoted by IAP LTR) is present only in placentas of C3H/HeJ and BALB/c mice. Both of these strains contain an IAP LTR in the MIPP gene. In contrast, there is no IAP LTR in this cellular gene in strains DBA/2J, C57BL/6J, and AKR/J. Thus, the IAP MIPP retrotransposition is strain-specific. The parents of the outbred CF-1 mice used for the present studies were both heterozygous at the MIPP locus. Restriction fragment length polymorphism studies using inbred strains and recombinant inbred mice have further established the linkage between the MIPP gene (D4Jhu8) and several loci on distal mouse chromosome 4. The symbol Ipp is being used for this gene in all major mouse data bases and in the comparative section of the human genome data base.
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