ArticleThe American journal of pathology1995
Developmental expression of the nephritogenic antigen of monoclonal antibody 5-1-6.
Article in The American journal of pathology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 61 citations in OpenAlex.
- Cdc42 Activation in Antinephrin Antibody-Induced Nephropathy.Journal of the American Society of Nephrology : JASN · 2025Article
- A simple protocol to establish a conditionally immortalized mouse podocyte cell line.Scientific reports · 2024Article
- New insight into podocyte slit diaphragm, a therapeutic target of proteinuria.Clinical and experimental nephrology · 2020Review
- Resolvin D1 Protects Against Ischemia/Reperfusion-Induced Acute Kidney Injury by Increasing Treg Percentages via the ALX/FPR2 Pathway.Frontiers in physiology · 2020Article
- Role of calcineurin (CN) in kidney glomerular podocyte: CN inhibitor ameliorated proteinuria by inhibiting the redistribution of CN at the slit diaphragm.Physiological reports · 2016Article
- Cell Therapy Using Human Induced Pluripotent Stem Cell-Derived Renal Progenitors Ameliorates Acute Kidney Injury in Mice.Stem cells translational medicine · 2015Article
- Nephrin and Podocin functions are highly conserved between the zebrafish pronephros and mammalian metanephros.Molecular medicine reports · 2014Article
- Developmental localization of nephrin in zebrafish and medaka pronephric glomerulus.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2013Article
- Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography.The Journal of clinical investigation · 2004Article
- Podocin localizes in the kidney to the slit diaphragm area.The American journal of pathology · 2002Article
- Role of nephrin in cell junction formation in human nephrogenesis.The American journal of pathology · 2000Article
- Nephritogenic mAb 5-1-6 is directed at the extracellular domain of rat nephrin.The Journal of clinical investigation · 1999Article
- Nephrin is specifically located at the slit diaphragm of glomerular podocytes.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Structure and function of podocytes: an update.Anatomy and embryology · 1995Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The biogenesis of p51, the target of nephritogenic monoclonal antibody 5-1-6, was studied in the developing glomerulus by immunolocalization and metabolic labeling. The localization of p51 was compared with that of ZO-1, a component of the cytoplasmic face of the epithelial slit diaphragm, and with that of podocalyxin, and apical marker of the podocyte. p51 first became faintly, but clearly, detectable on the basal and lateral sides of the developing podocytes at the S-shaped body stage. Staining intensity increased with further maturation and was restricted to the visceral epithelial cells. On immunoelectron microscopy, the antigen was seen along the basal and lateral surfaces below occluding junction at the early capillary loop stage and later, with the interdigitation of foot processes, became concentrated in the slit pores. At no stage was p51 seen on the apical surface. p51 and ZO-1 were closely localized in the mature glomerulus but arrived at their final positions from opposite directions. p51 was on basal and podocalyxin was on apical sides of the glomerular epithelium from the S-shaped body stage onwards. Metabolic labeling studies showed that p51 is actively synthesized during initial glomerular development and that the rate of synthesis declines substantially with maturation. We conclude that p51 is primarily synthesized during the initial glomerular development, becomes concentrated in the slit pores of mature podocytes, and serves as a basal differentiation marker for podocytes.
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Identifiers
7677194PMC1870958W1488563665What OpenQuestion holds
Registered trials
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