ArticleThe American journal of pathology1995
Active proliferation of different cell types, including lymphocytes, in human atherosclerotic plaques.
Article in The American journal of pathology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 154 citations in OpenAlex.
- Long-term effects of daily hemodialysis on vascular access outcomes: a prospective controlled study.Hemodialysis international. International Symposium on Home Hemodialysis · 2013Trial
- A loss-of-function polymorphism in the propeptide of lysyl oxidase exacerbates atherosclerosis.JCI insight · 2026Article
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- Bench-to-Bedside in Vascular Medicine: Optimizing the Translational Pipeline for Patients With Peripheral Artery Disease.Circulation research · 2021Review
- Characterizing the Role of Glycogen Synthase Kinase-3α/β in Macrophage Polarization and the Regulation of Pro-Atherogenic Pathways in Cultured LdlrFrontiers in immunology · 2021Article
- Trafficking of Mononuclear Phagocytes in Healthy Arteries and Atherosclerosis.Frontiers in immunology · 2021Review
- Review
- Inhibition of macrophage proliferation dominates plaque regression in response to cholesterol lowering.Basic research in cardiology · 2020Article
- Etosis, rather than apoptosis or cell proliferation, typifies thrombus progression - An immunohistochemical study of coronary aspirates.International journal of cardiology. Heart & vasculature · 2020Article
- Establishment of Novel Murine Model showing Vascular Inflammation-derived Cognitive Dysfunction.Scientific reports · 2019Article
- Macrophages and Cardiovascular Health.Physiological reviews · 2018Review
- Thermoneutrality but Not UCP1 Deficiency Suppresses Monocyte Mobilization Into Blood.Circulation research · 2017Article
- The 9p21.3 risk locus for coronary artery disease: A 10-year search for its mechanism.Journal of Taibah University Medical Sciences · 2017Review
- Macrophages in vascular inflammation and atherosclerosis.Pflugers Archiv : European journal of physiology · 2017Review
- Substrate elasticity regulates the behavior of human monocyte-derived macrophages.European biophysics journal : EBJ · 2016Article
- Development and Function of Arterial and Cardiac Macrophages.Trends in immunology · 2016Review
- Inhibiting macrophage proliferation suppresses atherosclerotic plaque inflammation.Science advances · 2015Article
- Lifestyle effects on hematopoiesis and atherosclerosis.Circulation research · 2015Review
- Human coronary heart disease: importance of blood cellular miR-2909 RNomics.Molecular and cellular biochemistry · 2014Article
- Histopathological changes due to the effect of selenium in experimental cockerels.The Indian journal of medical research · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cell proliferation, an important mechanism of atherosclerotic plaque growth, occurs among smooth muscle, inflammatory cell, and other cell types. We have identified different topographical patterns of cell proliferation in human carotid plaques, based on cell type. Cell proliferation was determined with an antibody to the proliferating cell nuclear antigen (PCNA), combined with cell type-specific antibodies. Despite low levels of overall proliferative activity, the intima displayed more proliferative activity than the underlying media (1.61 +/- 0.35% in intima versus 0.05 +/- 0.03% in media; P < 0.01). The preponderant proliferative cell type in the intima was the monocyte/macrophage (46.0% of PCNA-positive cells), with a minority being smooth muscle alpha-actin-positive (9.7%), microvascular endothelial (14.3%), and T cells (13.1%). Smooth muscle cells were the dominant proliferating cell type in the media (44.4% of PCNA-positive cells versus 20% endothelial cells, 13.0% monocyte/macrophages, and 14.3% T cells). Within the plaque, foam-cell-rich regions mostly displayed proliferation among macrophages (66.5%), whereas in vascularized fields PCNA positivity was almost equally shared by endothelial cells (23.8%), monocyte/macrophages (26.3%), smooth muscle alpha-actin-positive cells (14.0%), and to a lesser extent, T cells (8.2%). Logistic and linear regression analyses also demonstrated that location in foam-cell-rich regions was a significant predictor of proliferation only among monocyte/macrophages, whereas location in vascularized regions was a good predictor of PCNA positivity among both inflammatory and noninflammatory cells. These different patterns of cell type proliferation suggest possibly different distributions of putative responsible growth regulatory factors in human atherosclerosis.
Indexed as
Identifiers
7677178PMC1870963W1211632029What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.