ArticlePflugers Archiv : European journal of physiology1995
Fast exocytosis and endocytosis triggered by depolarisation in single adrenal chromaffin cells before rapid Ca2+ current run-down.
Article in Pflugers Archiv : European journal of physiology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 68 citations in OpenAlex.
- Chromaffin Cells of the Adrenal Medulla: Physiology, Pharmacology, and Disease.Comprehensive Physiology · 2019Article
- Syndapin 3 modulates fusion pore expansion in mouse neuroendocrine chromaffin cells.American journal of physiology. Cell physiology · 2014Article
- Complexin facilitates exocytosis and synchronizes vesicle release in two secretory model systems.The Journal of physiology · 2013Article
- Activity-dependent fusion pore expansion regulated by a calcineurin-dependent dynamin-syndapin pathway in mouse adrenal chromaffin cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Pituitary adenylate cyclase-activating peptide (PACAP) recruits low voltage-activated T-type calcium influx under acute sympathetic stimulation in mouse adrenal chromaffin cells.The Journal of biological chemistry · 2011Article
- Rapid endocytosis and vesicle recycling in neuroendocrine cells.Cellular and molecular neurobiology · 2010Review
- Permissive role of sphingosine on calcium-dependent endocytosis in chromaffin cells.Pflugers Archiv : European journal of physiology · 2010Article
- Dynamin I plays dual roles in the activity-dependent shift in exocytic mode in mouse adrenal chromaffin cells.Archives of biochemistry and biophysics · 2008Article
- Low frequency stimulation of mouse adrenal slices reveals a clathrin-independent, protein kinase C-mediated endocytic mechanism.The Journal of physiology · 2003Article
- Exocytosis in bovine chromaffin cells: studies with patch-clamp capacitance and FM1-43 fluorescence.Biophysical journal · 2002Article
- Dynamin-dependent and dynamin-independent processes contribute to the regulation of single vesicle release kinetics and quantal size.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Physiological stimuli evoke two forms of endocytosis in bovine chromaffin cells.The Journal of physiology · 2001Article
- Sustained stimulation of exocytosis triggers continuous membrane retrieval in rat pituitary somatotrophs.The Journal of physiology · 2001Article
- Real-time studies of zymogen granule exocytosis in intact rat pancreatic acinar cells.The Journal of physiology · 2000Article
- Munc13-1 acts as a priming factor for large dense-core vesicles in bovine chromaffin cells.The EMBO journal · 2000Article
- Properties of fast endocytosis at hippocampal synapses.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1999Article
- A persistent activity-dependent facilitation in chromaffin cells is caused by Ca2+ activation of protein kinase C.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Barium triggers rapid endocytosis in calf adrenal chromaffin cells.The Journal of physiology · 1998Article
- Compensatory and excess retrieval: two types of endocytosis following single step depolarizations in bovine adrenal chromaffin cells.The Journal of physiology · 1998Article
- Two forms of triggered endocytosis in regulated secretory cells.The Journal of physiology · 1998Review
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The kinetics of exocytosis and membrane retrieval (endocytosis) were examined in bovine chromaffin cells using membrane capacitance measurement during whole-cell recording. At early times after breakthrough to the whole-cell recording mode, depolarisation for 1 s resulted in a fast (600 vesicles per s) exocytotic response and efficient membrane retrieval with a time constant of 25 s. The ability to activate fast exocytosis and retrieval was lost during intracellular dialysis, with a time constant of 40 s. At later times, a slow exocytotic response could be elicited with no membrane retrieval following single depolarisations. The wash-out of the responses appeared to be due to a rapid loss of a portion of the Ca2+ current. Trains of depolarisation at late times after breakthrough could elicit a fast (time constant 4 s) retrieval. These data show that in addition to a previously studied slow Ca(2+)-independent retrieval mechanism, chromaffin cells also possess an efficient and rapid retrieval pathway coupled to exocytosis that can be activated following depolarisation. The fast endocytosis appears to have a higher threshold for activation than exocytosis, probably due to a higher Ca2+ requirement. Rapid membrane retrieval appears to occur via a clathrin-independent pathway in chromaffin cells.
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