Trial reportJournal of neurology, neurosurgery, and psychiatry1995
A controlled study of potential risk factors preceding exacerbation in multiple sclerosis.
Trial report in Journal of neurology, neurosurgery, and psychiatry, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Factors associated with relapses in relapsing-remitting multiple sclerosis: A systematic review and meta-analysis.Medicine · 2020Pooled it
- Association between stressful life events and exacerbation in multiple sclerosis: a meta-analysis.BMJ (Clinical research ed.) · 2004Pooled it
- Stressful life events and depression and fatigue in people with multiple sclerosis: a cross-sectional analysis of an international cohort.Acta neurologica Belgica · 2024Article
- The Level of Stress and Coping Strategies in Patients with Multiple Sclerosis and Their Relationships with the Disease Course.Journal of clinical medicine · 2021Article
- Content Validity of an Integrated Yoga Module for Practice During Remission in Relapsing-Remitting Multiple Sclerosis Patients.Annals of neurosciences · 2021Article
- Stress and multiple sclerosis: A systematic review considering potential moderating and mediating factors and methods of assessing stress.Health psychology open · 2015Review
- Stressful life events and multiple sclerosis: a retrospective study.Italian journal of neurological sciences · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A wide variety of potential risk factors for acute exacerbations in multiple sclerosis were evaluated in a one year case-control study. Eighty nine consecutive patients with clinically definite multiple sclerosis and relapsing remitting course presenting with a relapse between January and December 1992 were compared with patients matched for age, sex, and degree of disability, who did not experience clinical exacerbations during the same period. Only potential risk factors occurring in the three months preceding the interview were considered patients. Relapsing patients reported no significant increase in the frequency of any risk factor in the three month period before exacerbation compared with the control group. These results suggest that most relapses are not preceded by the conditions commonly considered as risk factors.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.