Trial reportGut1995
A controlled study of bone mineral density in patients with inflammatory bowel disease.
Trial report in Gut, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Guideline
- High-resolution Quantitative Computed Tomography Demonstrates Structural Defects in Cortical and Trabecular Bone in IBD Patients.Journal of Crohn's & colitis · 2016Trial
- Adalimumab Therapy Has a Beneficial Effect on Bone Metabolism in Patients with Crohn's Disease.Digestive diseases and sciences · 2015Trial
- Bones and Crohn's: no benefit of adding sodium fluoride or ibandronate to calcium and vitamin D.World journal of gastroenterology · 2011Trial
- Effect of exclusive enteral nutrition on bone turnover in children with Crohn's disease.Journal of gastroenterology · 2010Trial
- Inflammatory Bowel Disease and Periprosthetic Joint Infection Following Total Joint Arthroplasty: Crohn's Disease and Ulcerative Colitis Associated With Varying Risk.Arthroplasty today · 2026Article
- The association between theFrontiers in genetics · 2026Article
- Hypercalcaemia due to isolated elevation of 1,25-dihydroxyvitamin D in patients with Crohn's disease.BMJ case reports · 2019Article
- Reduced bone mass and preserved marrow adipose tissue in patients with inflammatory bowel diseases in long-term remission.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Article
- Risk factors for developing colorectal cancer in Japanese patients with ulcerative colitis: a retrospective observational study-CAPITAL (Cohort and Practice for IBD total management in Kyoto-Shiga Links) study I.BMJ open gastroenterology · 2016Article
- Sex-Specific Issues in Inflammatory Bowel Disease.Gastroenterology & hepatology · 2015Article
- Nutrient intake and bone mineral density by nutritional status in patients with inflammatory bowel disease.Journal of bone metabolism · 2014Article
- High vitamin D3 diet administered during active colitis negatively affects bone metabolism in an adoptive T cell transfer model.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
- The prevalence and risk factors of decreased bone mineral density in firstly diagnosed ulcerative colitis patients in the eastern region of Turkey.International journal of clinical and experimental medicine · 2011Article
- Clinical relevance of changes in bone metabolism in inflammatory bowel disease.World journal of gastroenterology · 2010Review
- Incidence and risk of intestinal and extra-intestinal complications in Medicaid patients with inflammatory bowel disease: a 5-year population-based study.Digestive diseases and sciences · 2010Article
- High prevalence of vitamin K and D deficiency and decreased BMD in inflammatory bowel disease.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2009Article
- Risk factors for low bone mineral density in children and adolescents with inflammatory bowel disease.Digestive diseases and sciences · 2008Article
- Improvement of lumbar bone mass after infliximab therapy in Crohn's disease patients.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2007Article
- Bone mineral density in Iranian patients with inflammatory bowel disease.International journal of colorectal disease · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To assess the prevalence of and risk factors for low bone mineral density in inflammatory bowel disease (IBD), 152 IBD patients and 73 healthy controls were studied. Sixty seven patients had ulcerative colitis, 78 had Crohn's disease (52 of them (66.7%) had ileal disease), and seven had indeterminate colitis. Bone mineral density values (g/cm2) measured by dual energy x ray absorbtiometry at the spine (L2-L4), the femoral neck, Ward's triangle, and the trochanter were 1.177, 0.948, 0.850, and 0.838 in the patients and 1.228 (p = 0.034), 1.001 (p = 0.009), 0.889 (NS), and 0.888 (p = 0.012) in the control group, respectively. The type or extent of the disease or previous small bowel resection did not have any significant effect on the bone mineral density values. There was a weak, but statistically significant negative correlation between bone mineral density and the total lifetime corticosteroid dose (in the lumbar spine r = -0.164, p = 0.04, the femoral neck r = -0.185, p = 0.02, Ward's triangle r = -0.167, p = 0.04, and the trochanter r = -0.237, p = 0.003). The patients whose lifetime corticosteroid dose (prednisone/prednisolone) was more than 10 g had especially low bone mineral density (p < 0.05 compared with the groups with no or less than 5 g of corticosteroid). The patients who had never taken peroral corticosteroids did not have decreased bone mineral density. In conclusion, IBD patients have significantly lower bone mineral density values than healthy controls, but the difference is not so great as has been reported previously. Low bone mineral density values in these patients are related to high lifetime corticosteroid doses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.