ArticleBritish journal of pharmacology1995
Autoradiography of P2x ATP receptors in the rat brain.
Article in British journal of pharmacology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 64 citations in OpenAlex.
- Review
- Reductions in COQ2 Expression Relate to Reduced ATP Levels in Multiple System Atrophy Brain.Frontiers in neuroscience · 2019Article
- Mapping P2X and P2Y receptor proteins in striatum and substantia nigra: An immunohistological study.Purinergic signalling · 2007Article
- Purinergic modulation of cardiovascular function in the rat locus coeruleus.British journal of pharmacology · 2005Article
- Role for P2X receptors in long-term potentiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Purinergic and adrenergic agonists synergize in stimulating vasopressin and oxytocin release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Single channel properties of P2X ATP receptors in outside-out patches from rat hippocampal granule cells.The Journal of physiology · 2000Article
- ATP-mediated glia signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Synaptic control of motoneuronal excitability.Physiological reviews · 2000Review
- Central P2X4 and P2X6 channel subunits coassemble into a novel heteromeric ATP receptor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Ca2+ signals mediated by P2X-type purinoceptors in cultured cerebellar Purkinje cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Nucleotide receptors in the nervous system. An abundant component using diverse transduction mechanisms.Molecular neurobiology · 1997Review
- P2 receptor excitation of rodent hypoglossal motoneuron activity in vitro and in vivo: a molecular physiological analysis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- PExpert opinion on investigational drugs · 1995Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Binding of a P2x receptor specific radioligand, [3H]-alpha,beta-methylene adenosine triphosphate ([3H]-alpha,beta-MeATP) to sections of rat brain was reversible and association/dissociation parameters indicated that it consisted of two saturable components. Non-specific binding was very low (< 7% at 10 nM ligand concentration). 2. The binding was completely inhibited by suramin (IC50 approximately 14-26 microM) but none of the ligands specific for P2y receptors such as 2-methylthio-adenosine triphosphate (2-methyl-S-ATP) and 2-chloro-adenosine triphosphate (2-C1-ATP) nor 2-methylthio-adenosine diphosphate (2-methyl-S-ADP) a ligand for the P2 receptor on blood platelets ('P2T' type) produced strong inhibitions except for P1,P4-di(adenosine-5')tetraphosphate (Ap4A). 3. Inhibitors of Na+,K(+)-dependent adenosine triphosphatase (ATPase) ouabain, P1-ligand adenosine and an inhibitor of transport of, respectively, adenosine and cyclic nucleotides, dilazep, had no effect. 4. The highest density of P2x binding sites was found to be in the cerebellar cortex but the binding sites were present in all major brain regions, especially in areas known to receive strong excitatory innervation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.