ArticleBiophysical journal1995
The rise times of miniature endplate currents suggest that acetylcholine may be released over a period of time.
Article in Biophysical journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Control of neurotransmitter release by an internal gel matrix in synaptic vesicles.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Vesicle size and transmitter release at the frog neuromuscular junction when quantal acetylcholine content is increased or decreased.The Journal of physiology · 2002Article
- The temperature sensitivity of miniature endplate currents is mostly governed by channel gating: evidence from optimized recordings and Monte Carlo simulations.Biophysical journal · 1999Article
- The effects of geometrical parameters on synaptic transmission: a Monte Carlo simulation study.Biophysical journal · 1997Article
- Synaptic transmission at visualized sympathetic boutons: stochastic interaction between acetylcholine and its receptors.Biophysical journal · 1997Article
- Analytical description of the activation of multi-state receptors by continuous neurotransmitter signals at brain synapses.Biophysical journal · 1997Article
- A mechanism for discharge of charged excitatory neurotransmitter.Biophysical journal · 1997Article
- A mathematical description of miniature postsynaptic current generation at central nervous system synapses.Biophysical journal · 1996Article
- Miniature endplate current rise times less than 100 microseconds from improved dual recordings can be modeled with passive acetylcholine diffusion from a synaptic vesicle.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Accounting for the shapes and size distributions of miniature endplate currents.Biophysical journal · 1996Article
- Neurotransmitter discharge and postsynaptic rise times.Biophysical journal · 1996Article
- Spontaneous and uniquantal-evoked endplate currents in normal frogs are indistinguishable.The Journal of physiology · 1996Article
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Abstract
Models of miniature endplate currents predict 20-80% rise times of 100 microseconds or less. These predictions are substantially less than most of the rise times recorded in the literature. New measurements were made of rise times at the frog neuromuscular junction using extracellular recording. The mean 20-80% rise time was 250 microseconds. Rise times were variable; at 20 degrees C, 95% of them fell in a range from 140 to 460 microseconds. The most questionable assumption in the models is that the acetylcholine (ACh) is released instantaneously. Modifying the model, so that ACh diffuses from the vesicle through a pore, lengthens the rise time to observed levels. It has been proposed that ACh is released from the vesicle in exchange for Na+. However, the rise times of miniature endplate currents recorded in solutions in which the Na+ is replaced by sucrose are in the normal range. The Q10 for the rise of miniature endplate currents is approximately 2, which is consistent with the models and with temperature effects on pore formation in mast cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.