ArticleBritish journal of cancer1995
Loss of heterozygosity at chromosome 11 in breast cancer: association of prognostic factors with genetic alterations.
Article in British journal of cancer, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Trial
- Hippo-TAZ signaling is the master regulator of the onset of triple-negative basal-like breast cancers.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- ASB13 inhibits breast cancer metastasis through promoting SNAI2 degradation and relieving its transcriptional repression of YAP.Genes & development · 2020Article
- WW-Domain Containing Protein Roles in Breast Tumorigenesis.Frontiers in oncology · 2018Review
- Polymorphisms in CARS are associated with gastric cancer risk: a two-stage case-control study in the Chinese population.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2017Article
- YAP enhances autophagic flux to promote breast cancer cell survival in response to nutrient deprivation.PloS one · 2015Article
- Differences and homologies of chromosomal alterations within and between breast cancer cell lines: a clustering analysis.Molecular cytogenetics · 2014Article
- Nuclear localization of the transcriptional coactivator YAP is associated with invasive lobular breast cancer.Cellular oncology (Dordrecht, Netherlands) · 2013Article
- Pathology of hereditary breast cancer.Cellular oncology (Dordrecht, Netherlands) · 2011Review
- Frequent loss of the BLID gene in early-onset breast cancer.Cytogenetic and genome research · 2011Article
- Association between common germline genetic variation in 94 candidate genes or regions and risks of invasive epithelial ovarian cancer.PloS one · 2009Article
- Article
- Article
- Analysis of CUL-5 expression in breast epithelial cells, breast cancer cell lines, normal tissues and tumor tissues.Molecular cancer · 2003Article
- Organization, chromosomal localization and promoter analysis of the gene encoding human acidic fibroblast growth factor intracellular binding protein.The Biochemical journal · 2000Article
- Localization of multiple melanoma tumor-suppressor genes on chromosome 11 by use of homozygosity mapping-of-deletions analysis.American journal of human genetics · 2000Article
- Functional localization of a melanoma tumor suppressor gene to a small (< or = 2 Mb) region on 11q23.Oncogene · 1999Article
- European multicenter study on LOH of APOC3 at 11q23 in 766 breast cancer patients: relation to clinical variables. Breast Cancer Somatic Genetics Consortium.British journal of cancer · 1999Article
- Frequent allelic losses at 11q24.1-q25 in young women with breast cancer: association with poor survival.British journal of cancer · 1999Article
- Loss of heterozygosity on chromosome 11p15 during histological progression in microdissected ductal carcinoma of the breast.The American journal of pathology · 1998Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined DNA from 116 female and four male breast cancer patients for loss of heterozygosity (LOH). DNA was analysed by polymerase chain reaction using ten microsatellite markers on chromosome 11. Three distinct regions of LOH were identified: 11p15.5, 11q13 and 11q22-qter with a LOH frequency of 19, 23 and 37-43% respectively. The marker D11S969 showing the highest frequency of LOH (43%) is located at the 11q24.1-q25 region. No previous molecular genetic studies have shown frequent LOH at the region telomeric to q23 on chromosome 11. Southern analysis revealed that LOH at 11q13 was due to amplification, whereas LOH at 11q22qter was due to deletion. LOH at 11p15.5 was associated with paucity of hormone receptor proteins, high S-phase and positive node status. An association was found between LOH at 11q13 and positive node status. LOH at the 11q22-qter region correlated with a high S-phase fraction. A significant association was found between LOH at 11p15 and chromosome regions 17q21 (the BRCA1 region) and 3p.
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