ReviewDrug safety1995
Absorption interactions with fluoroquinolones. 1995 update.
Review in Drug safety, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- The effect of zinc supplementation on blood pressure: a systematic review and dose-response meta-analysis of randomized-controlled trials.European journal of nutrition · 2020Pooled it
- Effect of food or antacid on pharmacokinetics and pharmacodynamics of febuxostat in healthy subjects.British journal of clinical pharmacology · 2008Trial
- Effects of enteral feeding on the oral bioavailability of moxifloxacin in healthy volunteers.Clinical pharmacokinetics · 2005Trial
- Effect of calcium carbonate on bioavailability of orally administered gemifloxacin.Antimicrobial agents and chemotherapy · 2003Trial
- Lack of pharmacokinetic interaction between the oral anti-influenza neuraminidase inhibitor prodrug oseltamivir and antacids.British journal of clinical pharmacology · 2002Trial
- Lack of effect of simultaneously administered didanosine encapsulated enteric bead formulation (Videx EC) on oral absorption of indinavir, ketoconazole, or ciprofloxacin.Antimicrobial agents and chemotherapy · 2002Trial
- Effects of sucralfate on the oral bioavailability of moxifloxacin, a novel 8-methoxyfluoroquinolone, in healthy volunteers.Clinical pharmacokinetics · 2001Trial
- Effects of iron supplements on the oral bioavailability of moxifloxacin, a novel 8-methoxyfluoroquinolone, in humans.Clinical pharmacokinetics · 2001Trial
- Effects of dairy products on the oral bioavailability of moxifloxacin, a novel 8-methoxyfluoroquinolone, in healthy volunteers.Clinical pharmacokinetics · 2001Trial
- Zinc Toxicity: Understanding the Limits.Molecules (Basel, Switzerland) · 2024Review
- Burden of enteral supplement interactions with common antimicrobial agents: a single-centre observational analysis.European journal of hospital pharmacy : science and practice · 2022Observational
- Treatment of pigs with enrofloxacin via different oral dosage forms - environmental contaminations and resistance development ofJournal of veterinary science · 2022Article
- Prediction of potential drug interactions between repurposed COVID-19 and antitubercular drugs: an integrational approach of drug information software and computational techniques data.Therapeutic advances in drug safety · 2021Article
- Permeation characteristics of tetracyclines in parallel artificial membrane permeation assay II: Effect of divalent metal ions and mucin.ADMET & DMPK · 2020Article
- Zinc Deficiency in Men Over 50 and Its Implications in Prostate Disorders.Frontiers in oncology · 2020Review
- Revisiting Oral Fluoroquinolone and Multivalent Cation Drug-Drug Interactions: Are They Still Relevant?Antibiotics (Basel, Switzerland) · 2019Review
- Treatment of the Fluoroquinolone-Associated Disability: The Pathobiochemical Implications.Oxidative medicine and cellular longevity · 2017Review
- Biomarkers of Nutrition for Development (BOND)-Zinc Review.The Journal of nutrition · 2015Article
- Pharmacokinetic interaction of ciprofloxacin with diclofenac: a single-dose, two-period crossover study in healthy adult volunteers.Clinical drug investigation · 2009Article
- Pharmacokinetic and pharmacodynamic studies of drug interaction following oral administration of imipramine and sodium alginate in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The utility of the fluoroquinolone class of antibiotics is rapidly expanding due to their favourable pharmacokinetic profile and the continuing development of new compounds. These agents are often used for indications not successfully treated with other orally available antimicrobials in the past, or for 'step-down' therapy in patients originally treated with intravenous agents. As the usage of these agents expands for serious systemic infections, knowledge of absorptive interactions with fluoroquinolones becomes paramount. Fluoroquinolones are often utilised in dosages and against modestly susceptible pathogens which allow a narrow margin for acceptable decreases in bioavailability. Chelation interactions with multivalent cations can result in inactivation of the fluoroquinolone with ramifications in vitro and in vivo. Chelation interactions have been reported to occur in between 22 and 76% of patients prescribed fluoroquinolones. Concurrent administration of magnesium-aluminum antacids and sucralfate has the greatest effect on the bioavailability of quinolones followed by iron, calcium and zinc. Spacing doses of fluoroquinolones and interactants has been suggested as a method of ensuring adequate quinolone absorption, but this can make optimal administration of the cation interactant difficult, if not impossible.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.