Evidence map›Paper›PMID 7668292›Full record

ArticleAmerican journal of human genetics1995

Linkage analyses of chromosome 18 markers do not identify a major susceptibility locus for bipolar affective disorder in the Old Order Amish.

D L Pauls, J Ott, S M Paul, C R Allen, C S Fann, J P Carulli, K M Falls, C A Bouthillier, T C Gravius, T P Keith

Open access · greenAbstract read
In one paragraph

Article in American journal of human genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Molecular linkage studies of bipolar disorder.Dialogues in clinical neuroscience · 1999
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

D L PaulsChild Study Center, Yale University School of Medicine, New Haven, CT 06510-8009, USA.
J Ott
S M Paul
C R Allen
C S Fann
J P Carulli
K M Falls
C A Bouthillier
T C Gravius
T P Keith
Yale University · US

Funding

LINKAGE ANALYSIS METHODS IN SCHIZOPHRENIAR01MH044292 · NIMH · ROCKEFELLER UNIVERSITY · PI OTT, JURG · 1989 to 2008
$1.3M
LINKAGE ANALYSIS METHODS IN SCHIZOPHRENIAR37MH044292 · NIMH · ROCKEFELLER UNIVERSITY · PI OTT, JURG · 1993 to 2002
$788k
GENETIC STUDIES OF AFFECTIVE DISORDERS AMONG AMISHR01MH028287 · NIMH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI EGELAND, JANICE A · 1985 to 1994
–
NIMH NIH HHS MH-00508NIMH NIH HHS MH28287NIMH NIH HHS MH44292
6 · The paper itself

Abstract

Previously reported linkage of bipolar affective disorder to DNA markers in the pericentromeric region of chromosome 18 was reexamined in a larger homogeneous sample of Old Order Amish families. Four markers (D18S21, D18S53, D18S44, and D18S40) were examined in three kindreds containing 31 bipolar I (BP I) individuals. Although linkage findings were replicated in the one previously studied Amish pedigree containing four BP I individuals, linkage to this region was excluded in the larger sample. If a susceptibility locus for bipolar disorder is located in this region of chromosome 18, it is of minor significance in this population.

Indexed as

Chromosomes, Human, Pair 18Genetic LinkageBipolar DisorderChromosome MappingEthnicityFemaleGenetic MarkersGenotypeHumansLod ScoreMaleGenetic Markers

Identifiers

PMID7668292
PMCPMC1801276
OpenAlexW1934905742

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.