ArticleAmerican journal of human genetics1995
Nonsyndromic cleft lip with or without cleft palate: evidence of linkage to BCL3 in 17 multigenerational families.
Article in American journal of human genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 114 citations in OpenAlex.
- Oral cleft prevention program (OCPP).BMC pediatrics · 2012Trial
- Unveiling the multifaceted roles of BCL3: biological functions and disease implications.Apoptosis : an international journal on programmed cell death · 2026Review
- Review
- Fine-Mapping of 18q21.1 Locus Identifies Single Nucleotide Polymorphisms Associated with Nonsyndromic Cleft Lip with or without Cleft Palate.Frontiers in genetics · 2016Article
- TGFA and IRF6 contribute to the risk of nonsyndromic cleft lip with or without cleft palate in northeast China.PloS one · 2013Article
- A comprehensive review of the genetic basis of cleft lip and palate.Journal of oral and maxillofacial pathology : JOMFP · 2012Article
- Genetics and management of the patient with orofacial cleft.Plastic surgery international · 2012Article
- Nonsyndromic cleft lip and palate: CRISPLD genes and the folate gene pathway connection.Birth defects research. Part A, Clinical and molecular teratology · 2011Article
- Mutation analysis of the PVRL1 gene in caucasians with nonsyndromic cleft lip/palate.Genetic testing and molecular biomarkers · 2009Article
- Mutation and association analysis of the PVR and PVRL2 genes in patients with non-syndromic cleft lip and palate.Genetics and molecular biology · 2009Article
- Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate.Human molecular genetics · 2008Article
- A genome wide linkage scan for cleft lip and palate and dental anomalies.American journal of medical genetics. Part A · 2008Article
- Autosomal dominant nonsyndromic cleft lip and palate: significant evidence of linkage at 18q21.1.American journal of human genetics · 2007Article
- Genetics of cleft lip and palate : a review.The Malaysian journal of medical sciences : MJMS · 2007Article
- Genomewide scan for nonsyndromic cleft lip and palate in multigenerational Indian families reveals significant evidence of linkage at 13q33.1-34.American journal of human genetics · 2006Article
- Genetic evidence for the role of loci at 19q13 in cleft lip and palate.Journal of medical genetics · 2006Article
- Association of MSX1 and TGFB3 with nonsyndromic clefting in humans.American journal of human genetics · 1998Article
- Syndromic ectrodactyly with severe limb, ectodermal, urogenital, and palatal defects maps to chromosome 19.American journal of human genetics · 1998Article
- Genome scan for teratogen-induced clefting susceptibility loci in the mouse: evidence of both allelic and locus heterogeneity distinguishing cleft lip and cleft palate.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Molecular cloning and mapping of a novel developmentally regulated human C2H2-type zinc finger.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Nonsyndromic cleft lip with or without cleft palate (CL/P) is a common craniofacial developmental defect. Recent segregation analyses have suggested that major genes play a role in the etiology of CL/P. Linkage to 22 candidate genes was tested in 11 multigenerational families with CL/P, and 21 of these candidates were excluded. APOC2, 19q13.1, which is linked to the proto-oncogene BCL3, gave suggestive evidence for linkage to CL/P. The study was expanded to include a total of 39 multigenerational CL/P families. Linkage was tested in all families, using an anonymous marker, D19S178, and intragenic markers in BCL3 and APOC2. Linkage was tested under two models, autosomal dominant with reduced penetrance and affecteds only. Homogeneity testing on the two-point data gave evidence of heterogeneity at APOC2 under the affecteds-only model. Both models showed evidence of heterogeneity, with 43% of families linked at zero recombination to BCL3 when marker data from BCL3 and APOC2 were included. A maximum multipoint LOD score of 7.00 at BCL3 was found among the 17 families that had posterior probabilities > = 50% in favor of linkage. The transmission disequilibrium test provided additional evidence for linkage with the 3 allele of BCL3 more often transmitted to affected children. These results suggest that BCL3, or a nearby gene, plays a role in the etiology of CL/P in some families.
Indexed as
Identifiers
7668251PMC1801552W105781282What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.