ArticleNucleic acids research1995
The coding sequences of mouse H2A and H3 histone genes contains a conserved seven nucleotide element that interacts with nuclear factors and is necessary for normal expression.
Article in Nucleic acids research, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- YY1 associates with the macrosatellite DXZ4 on the inactive X chromosome and binds with CTCF to a hypomethylated form in some male carcinomas.Nucleic acids research · 2012Article
- Temporally and spatially controllable gene expression and knockout in mouse urothelium.American journal of physiology. Renal physiology · 2010Article
- Article
- Multiple independent evolutionary solutions to core histone gene regulation.Genome biology · 2006Article
- Drosophila stem loop binding protein coordinates accumulation of mature histone mRNA with cell cycle progression.Genes & development · 2001Article
- Role for a YY1-binding element in replication-dependent mouse histone gene expression.Molecular and cellular biology · 1998Article
- The mouse histone H2a gene contains a small element that facilitates cytoplasmic accumulation of intronless gene transcripts and of unspliced HIV-1-related mRNAs.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Cell cycle-regulated binding of nuclear proteins to elements within a mouse H3.2 histone gene.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Expression of replication-dependent histone genes of all classes is up-regulated coordinately at the onset of DNA synthesis. The cellular signals involved in coordinate regulation of these genes are not known. Here we report identification of an alpha element, present within the mouse histone coding region activating sequence (CRAS). We show evidence that this element is present in histone genes from two classes, H2a and H3, in the mouse. This element has two biological functions in histone gene expression, i.e. the element interacts with nuclear proteins in regulation of gene expression, as well as encoding the amino acids of the histone proteins. We present both in vivo and in vitro evidence that interaction of nuclear proteins with this element is required for normal expression. The binding site for nuclear protein(s) has been precisely defined by means of synthetic oligonucleotides, as well as DNase I protection and methylation interference. It is interesting to note that the histone CRAS alpha element is mutated in a replication-independent H3.3 gene; 5 of 7 nt in the CRAS alpha box are changed in this gene.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.