ArticlePflugers Archiv : European journal of physiology1995
Metabolic inhibition and low internal ATP activate K-ATP channels in rat dopaminergic substantia nigra neurones.
Article in Pflugers Archiv : European journal of physiology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 96 citations in OpenAlex.
- Association of diabetes with dyskinesia in older psychosis patients.Psychopharmacology · 2004Trial
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- Alpha-synuclein oligomers alter the spontaneous firing discharge of cultured midbrain neurons.Frontiers in cellular neuroscience · 2023Article
- CaScience advances · 2022Article
- Pathophysiological Features of Nigral Dopaminergic Neurons in Animal Models of Parkinson's Disease.International journal of molecular sciences · 2022Review
- Anti-aging effects of chlorpropamide depend on mitochondrial complex-II and the production of mitochondrial reactive oxygen species.Acta pharmaceutica Sinica. B · 2022Article
- Latest Insights into the Pathophysiology of Migraine: the ATP-Sensitive Potassium Channels.Current pain and headache reports · 2020Review
- Effects of nicorandil on p120 expression in the spinal cord and dorsal root ganglion of rats with chronic postsurgical pain.Molecular medicine reports · 2020Article
- Calcium, Bioenergetics, and Parkinson's Disease.Cells · 2020Review
- The expression of KAnnals of translational medicine · 2018Article
- Food Addiction, High-Glycemic-Index Carbohydrates, and Obesity.Clinical chemistry · 2018Review
- Neuroprotective role of ATP-sensitive potassium channels in cerebral ischemia.Acta pharmacologica Sinica · 2013Review
- Intracellular energy status regulates activity in hypocretin/orexin neurones: a link between energy and behavioural states.The Journal of physiology · 2011Article
- H2O2: a dynamic neuromodulator.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2011Review
- Stimulation of neuronal KATP channels by cGMP-dependent protein kinase: involvement of ROS and 5-hydroxydecanoate-sensitive factors in signal transduction.American journal of physiology. Cell physiology · 2010Article
- Ca2+ influx through NMDA-gated channels activates ATP-sensitive K+ currents through a nitric oxide-cGMP pathway in subthalamic neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Dual regulation of the ATP-sensitive potassium channel by activation of cGMP-dependent protein kinase.Pflugers Archiv : European journal of physiology · 2008Article
- Glibenclamide depletes ATP in renal proximal tubular cells by interfering with mitochondrial metabolism.British journal of pharmacology · 2005Article
- Endogenous hydrogen peroxide regulates the excitability of midbrain dopamine neurons via ATP-sensitive potassium channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Activation of ATP-sensitive K+ (K(ATP)) channels by H2O2 underlies glutamate-dependent inhibition of striatal dopamine release.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The patch-clamp technique was used to study whole-cell currents of acutely dissociated rat substantia nigra (SN) neurones. In perforated-patch current-clamp recordings, inhibition of mitochondrial metabolism by rotenone (5 microM) produced a hyperpolarisation and inhibited electrical activity. These effects were reversed by the sulphonylureas tolbutamide (0.5 mM) or glibenclamide (0.5 microM). Under voltage-clamp conditions, rotenone induced a time- and voltage-independent K+ current which was selectively blocked by sulphonylureas. The glibenclamide-sensitive current reversed at -81.7 +/- 2.7 mV (n = 5) and showed marked inward rectification. Intracellular dialysis with 0.3 mM adenosine 5'-triphosphate (ATP), but not 2 mM or 5 mM ATP, in standard whole-cell recordings also resulted in activation of a sulphonylurea-sensitive K+ current with similar properties (reversal potential, -81.9 +/- 2.5 mV, n = 5). The close similarity in the properties of the ATP-sensitive K+ current observed in whole-cell recordings and the K+ current activated by metabolic inhibition in perforated-patch recordings suggest that they both result from activation of the same type of ATP-sensitive K+ channel. Sulphonylureas had no effect on electrical activity or membrane currents in the absence of rotenone in perforated-patch recordings, or in cells dialysed with 5 mM ATP, indicating that in SN neurones these drugs are selective for the ATP-sensitive K+ current.
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