ArticleJournal of virology1995
Rapid induction of apoptosis by cell-to-cell transmission of human immunodeficiency virus type 1.
Article in Journal of virology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 60 citations in OpenAlex.
- Human retroviral antisense mRNAs are retained in the nuclei of infected cells for viral persistence.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Dysregulation of mitochondrial bioenergetics and quality control by HIV-1 Tat in cardiomyocytes.Journal of cellular physiology · 2018Article
- Retrovirus entry by endocytosis and cathepsin proteases.Advances in virology · 2012Article
- Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4.The Journal of clinical investigation · 2006Article
- Cytopathic killing of peripheral blood CD4(+) T lymphocytes by human immunodeficiency virus type 1 appears necrotic rather than apoptotic and does not require env.Journal of virology · 2002Article
- Binding of human immunodeficiency virus type 1 gp120 to CXCR4 induces mitochondrial transmembrane depolarization and cytochrome c-mediated apoptosis independently of Fas signaling.Journal of virology · 2001Article
- Positive and negative aspects of the human immunodeficiency virus protease: development of inhibitors versus its role in AIDS pathogenesis.Microbiology and molecular biology reviews : MMBR · 2000Review
- Cellular and viral specificities of human immunodeficiency virus type 1 vif protein.Journal of virology · 2000Article
- A carboxy-terminally truncated form of the human immunodeficiency virus type 1 Vpr protein induces apoptosis via G(1) cell cycle arrest.Journal of virology · 2000Article
- Applications of flow cytometry to clinical microbiology.Clinical microbiology reviews · 2000Review
- Ligation of the CD4 receptor induces activation-independent down-regulation of L-selectin.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein.Journal of virology · 1998Article
- CXCR4 and CD4 mediate a rapid CD95-independent cell death in CD4(+) T cells.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Role of the Fas/Fas ligand apoptotic pathway in human immunodeficiency virus type 1 disease.Journal of virology · 1998Review
- Delayed human immunodeficiency virus type 1-induced apoptosis in cells expressing truncated forms of CD4.Journal of virology · 1998Article
- Early increase of CD4+ CD45RA+ and CD4+ CD95- cells with conserved repertoire induced by anti-retroviral therapy in HIV-infected patients.Clinical and experimental immunology · 1998Article
- Transgenic dissection of HIV genes involved in lymphoid depletion.The Journal of clinical investigation · 1997Article
- Human immunodeficiency virus type 1 Vpr induces apoptosis following cell cycle arrest.Journal of virology · 1997Article
- Double-stranded RNA is a trigger for apoptosis in vaccinia virus-infected cells.Journal of virology · 1997Article
- Protease-defective, gp120-containing human immunodeficiency virus type 1 particles induce apoptosis more efficiently than does wild-type virus or recombinant gp120 protein in healthy donor-derived peripheral blood T cells.Journal of clinical microbiology · 1997Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The kinetics of human immunodeficiency virus type 1 (HIV-1)-induced cell death were investigated in cell-to-cell and cell-free models of virus transmission. Cocultivation of HIV-1 chronically infected H9 donor cells with uninfected H9 recipient cells resulted in rapid induction of programmed cell death. Within 8 h, apoptotic chromatin condensation was identified by histologic staining. In addition, many single cells with apoptotic nuclei were observed, indicating that stable cell fusion was not a requirement for apoptosis to occur. By 12 to 18 h of coculture, a DNA fragmentation ladder characteristic of apoptosis was detected by agarose gel electrophoresis. Quantitation of apoptosis by measurement of nuclear DNA content revealed that at least 20 to 30% of the nuclei were undergoing apoptosis by 24 h after cocultivation. The appearance of condensed nuclei and fragmented DNA occurred as HIV reverse transcription was completed, and it was not inhibited by zidovudine, suggesting that induction of apoptosis did not require new HIV replication. Soluble CD4 inhibited apoptosis, demonstrating that Env-CD4 interactions were required for apoptosis. In contrast to that in cell-to-cell transmission, apoptosis in cell-free HIV infections was markedly inefficient and was not observed until 70 to 90 h after infections were initiated. These findings indicate that HIV-1 induction of programmed destruction of the nucleus is initiated at the time of cell-cell cocultivation by a mechanism which requires CD4-Env interactions but not new HIV replication.
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