ArticleJournal of virology1995
Cooperation of simian virus 40 large and small T antigens in metabolic stabilization of tumor suppressor p53 during cellular transformation.
Article in Journal of virology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Wild-type p53 enhances efficiency of simian virus 40 large-T-antigen-induced cellular transformation.Journal of virology · 2009Article
- West Nile virus capsid protein induces p53-mediated apoptosis via the sequestration of HDM2 to the nucleolus.Cellular microbiology · 2008Article
- Conditionally replicating adenoviruses for cancer treatment.Current cancer drug targets · 2007Review
- The bacterial redox protein azurin induces apoptosis in J774 macrophages through complex formation and stabilization of the tumor suppressor protein p53.Infection and immunity · 2002Article
- Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Article
- Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase 1.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Article
- JNK targets p53 ubiquitination and degradation in nonstressed cells.Genes & development · 1998Article
- Identification of positive and negative regulatory regions involved in regulating expression of the human cytomegalovirus UL94 late promoter: role of IE2-86 and cellular p53 in mediating negative regulatory function.Journal of virology · 1998Article
- Inhibition of p53 transactivation function by the human T-cell lymphotropic virus type 1 Tax protein.Journal of virology · 1998Article
- A simian virus 40 large T-antigen segment containing amino acids 1 to 127 and expressed under the control of the rat elastase-1 promoter produces pancreatic acinar carcinomas in transgenic mice.Journal of virology · 1997Article
- MDM2 is a target of simian virus 40 in cellular transformation and during lytic infection.Journal of virology · 1997Article
- Tiny T antigen: an autonomous polyomavirus T antigen amino-terminal domain.Journal of virology · 1997Article
- Nuclear localization of the NS3 protein of hepatitis C virus and factors affecting the localization.Journal of virology · 1997Article
- Simian virus 40 small t antigen activates the carboxyl-terminal transforming p53-binding domain of large T antigen.Journal of virology · 1996Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolic stabilization of the tumor suppressor p53 is a key event in cellular transformation by simian virus 40 (SV40). Expression of the SV40 large tumor antigen (large T) is necessary but not sufficient for this process, as metabolic stabilization of p53 complexed to large T in abortively SV40-infected cells strictly depends on the cellular systems analyzed (F. Tiemann and W. Deppert, J. Virol. 68:2869-2878, 1994). Comparative analyses of various cells differing in metabolic stabilization of p53 upon abortive infection with SV40 revealed that metabolic stabilization of p53 closely correlated with expression of the SV40 small t antigen (small t) in these cells: 3T3 cells do not express small t and do not stabilize p53 upon infection with wild-type SV40. However, ectopic expression of small t in 3T3 cells provided these cells with the capacity to stabilize p53 upon SV40 infection. Conversely, precrisis mouse embryo cells express small t and mediate metabolic stabilization of p53 upon infection with wild-type SV40. Infection of these cells with an SV40 small-t deletion mutant did not lead to metabolic stabilization of p53. Small-t expression and metabolic stabilization of p53 correlated with an enhanced transformation efficiency by SV40, supporting the conclusion that at least part of the documented helper effect of small t in SV40 transformation is its ability to promote metabolic stabilization of p53 complexed to large T.
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