ArticleJournal of molecular evolution1995
Gene conversion vs point mutation in generating variability at the antigen recognition site of major histocompatibility complex loci.
Article in Journal of molecular evolution, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 54 citations in OpenAlex.
- Extensive MHC class IIβ diversity across multiple loci in the small-spotted catshark (Scyliorhinus canicula).Scientific reports · 2023Article
- A complex resistance locus in Solanum americanum recognizes a conserved Phytophthora effector.Nature plants · 2021Article
- Positive selection and climatic effects on MHC class II gene diversity in hares (Lepus capensis) from a steep ecological gradient.Scientific reports · 2018Article
- Article
- Retention of functional variation despite extreme genomic erosion: MHC allelic repertoires in the Lynx genus.BMC evolutionary biology · 2017Article
- MHC class II β exon 2 variation in pardalotes (Pardalotidae) is shaped by selection, recombination and gene conversion.Immunogenetics · 2017Article
- Drift, not selection, shapes toll-like receptor variation among oceanic island populations.Molecular ecology · 2015Article
- 454 screening of individual MHC variation in an endemic island passerine.Immunogenetics · 2015Article
- Genetic variation of the major histocompatibility complex (MHC class II B gene) in the threatened Hume's pheasant, Syrmaticus humiae.PloS one · 2015Article
- Evolutionary history of black grouse major histocompatibility complex class IIB genes revealed through single locus sequence-based genotyping.BMC genetics · 2013Article
- MHC class IIB exon 2 polymorphism in the Grey partridge (Perdix perdix) is shaped by selection, recombination and gene conversion.PloS one · 2013Article
- MHC evolution in three salmonid species: a comparison between class II alpha and beta genes.Immunogenetics · 2010Article
- Population genetic models of duplicated genes.Genetica · 2009Review
- Sequence features of HLA-DRB1 locus define putative basis for gene conversion and point mutations.BMC genomics · 2008Article
- TCR-MHC docking orientation: natural selection, or thymic selection?Immunologic research · 2008Review
- Full-length sequence analysis of the HLA-DRB1 locus suggests a recent origin of alleles.Immunogenetics · 2007Article
- Gene conversion between direct noncoding repeats promotes genetic and phenotypic diversity at a regulatory locus of Zea mays (L.).Genetics · 2006Article
- The diversity and evolutionary relationships of the pregnancy-associated glycoproteins, an aspartic proteinase subfamily consisting of many trophoblast-expressed genes.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Stem-loop potential in MHC genes: a new way of evaluating positive Darwinian selection?Immunogenetics · 1996Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to assess the roles of gene conversion followed by natural selection and balancing selection for point mutations in polymorphisms at major histocompatibility complex (MHC) loci, DNA sequences of several mammalian taxa were analyzed. Synonymous and nonsynonymous diversities were estimated separately for the antigen recognition site (ARS) and the remaining region of class I and class II genes. In some sequence pairs, the number of nonsynonymous substitutions exceeds that of synonymous substitutions at the ARS. This result indicates that some kind of balancing selection for point mutation is operating. In other sequence pairs (particularly of bovine and of rabbit), the number of synonymous substitutions at the ARS exceeds the same number at the remaining region. This result indicates that gene conversion involving a short region followed by natural selection is important. In general, a combination of gene conversion, point mutation, natural selection and random drift is thought to have contributed to polymorphisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.