ArticleThe Journal of physiology1995
Effects of phosphodiesterase inhibitors on spontaneous electrical activity (slow waves) in the guinea-pig gastric muscle.
Article in The Journal of physiology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- Inhibitory effect of caffeine on pacemaker activity in the oviduct is mediated by cAMP-regulated conductances.British journal of pharmacology · 2011Article
- Block of inhibitory junction potentials and TREK-1 channels in murine colon by Ca2+ store-active drugs.The Journal of physiology · 2008Article
- Electrical events underlying organized myogenic contractions of the guinea pig stomach.The Journal of physiology · 2006Review
- Atypical slow waves generated in gastric corpus provide dominant pacemaker activity in guinea pig stomach.The Journal of physiology · 2005Article
- Noradrenaline inhibits pacemaker currents through stimulation of beta 1-adrenoceptors in cultured interstitial cells of Cajal from murine small intestine.British journal of pharmacology · 2004Article
- ET-1-associated vasomotion and vasospasm in lymphatic vessels of the guinea-pig mesentery.British journal of pharmacology · 2003Article
- Muscarinic regulation of pacemaker frequency in murine gastric interstitial cells of Cajal.The Journal of physiology · 2003Article
- Pacemaker frequency is increased by sodium nitroprusside in the guinea pig gastric antrum.The Journal of physiology · 2003Article
- Regulation of pacemaker frequency in the murine gastric antrum.The Journal of physiology · 2002Article
- Generation of slow waves in the antral region of guinea-pig stomach--a stochastic process.The Journal of physiology · 2001Article
- Regulation of pacemaker currents in interstitial cells of Cajal from murine small intestine by cyclic nucleotides.The Journal of physiology · 2000Article
- Unitary nature of regenerative potentials recorded from circular smooth muscle of guinea-pig antrum.The Journal of physiology · 1999Article
- Identification of rhythmically active cells in guinea-pig stomach.The Journal of physiology · 1999Article
- Consequences of metabolic inhibition in smooth muscle isolated from guinea-pig stomach.The Journal of physiology · 1997Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The effects of the phosphodiesterase inhibitors caffeine, theophylline, isobutylmethylxanthine (IBMX) and rolipram on spontaneous electrical activity (slow waves) were studied in the circular muscle of the guinea-pig gastric antrum. 2. All the inhibitors reduced slow wave frequency without changing the membrane potential and the slow wave configuration, but at higher concentrations they blocked the slow waves and caused membrane hyperpolarization. In the presence of the inhibitors a low level of irregular electrical activity could be observed in many preparations. 3. Isoprenaline, forskolin, dibutyryl cAMP and 8-bromo-cAMP all produced effects essentially similar to those of phosphodiesterase inhibitors. K+ (12 mM) and removal of K+ both depolarized the membrane and these were not affected by IBMX (1-3 microM). A decrease in frequency caused by IBMX was also not significantly affected by 12 mM K+ or K+ removal and only partially antagonized by TEA or 4-aminopyridine. 4. These results suggest that an increase in intracellular cAMP inhibits pacemaker activity of slow waves. An increase in K+ conductance does not seem to be a major factor in this inhibition. Slow waves appear to be a compound electrical activity in a group of muscle cells and are likely to be disintegrated by xanthine derivatives.
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