ArticleThe Journal of physiology1995
Potassium currents in rat prevertebral and paravertebral sympathetic neurones: control of firing properties.
Article in The Journal of physiology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed.
- Sympathetic motor neuron dysfunction is a missing link in age-associated sympathetic overactivity.eLife · 2024Article
- Sympathetic Motor Neuron Dysfunction is a Missing Link in Age-Associated Sympathetic Overactivity.bioRxiv : the preprint server for biology · 2024Article
- Cellular and Molecular Mechanisms Underlying Altered Excitability of Cardiac Efferent Neurons in Cirrhotic Rats.Biomedicines · 2024Article
- Antagonism of the Muscarinic Acetylcholine Type 1 Receptor Enhances Mitochondrial Membrane Potential and Expression of Respiratory Chain Components via AMPK in Human Neuroblastoma SH-SY5Y Cells and Primary Neurons.Molecular neurobiology · 2022Article
- KCNQ Current Contributes to Inspiratory Burst Termination in the Pre-Bötzinger Complex of Neonatal RatsFrontiers in physiology · 2021Article
- Activation of SGK1.1 Upregulates the M-current in the Presence of Epilepsy Mutations.Frontiers in molecular neuroscience · 2021Article
- Downregulation of M Current Is Coupled to Membrane Excitability in Sympathetic Neurons Before the Onset of Hypertension.Hypertension (Dallas, Tex. : 1979) · 2020Article
- Early-life stress alters affective behaviors in adult mice through persistent activation of CRH-BDNF signaling in the oval bed nucleus of the stria terminalis.Translational psychiatry · 2020Article
- Chronic Stress Induces Maladaptive Behaviors by Activating Corticotropin-Releasing Hormone Signaling in the Mouse Oval Bed Nucleus of the Stria Terminalis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- A Calcium-Dependent Chloride Current Increases Repetitive Firing in Mouse Sympathetic Neurons.Frontiers in physiology · 2018Article
- The Role of Kv7/M Potassium Channels in Controlling Ectopic Firing in Nociceptors.Frontiers in molecular neuroscience · 2017Article
- Nonreciprocal mechanisms in up- and downregulation of spinal motoneuron excitability by modulators of KCNQ/Kv7 channels.Journal of neurophysiology · 2016Article
- Gq Protein-Coupled Membrane-Initiated Estrogen Signaling Rapidly Excites Corticotropin-Releasing Hormone Neurons in the Hypothalamic Paraventricular Nucleus in Female Mice.Endocrinology · 2016Article
- Virtual leak channels modulate firing dynamics and synaptic integration in rat sympathetic neurons: implications for ganglionic transmission in vivo.The Journal of physiology · 2015Article
- Augmentation of M-type (KCNQ) potassium channels as a novel strategy to reduce stroke-induced brain injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Forskolin suppresses delayed-rectifier K+ currents and enhances spike frequency-dependent adaptation of sympathetic neurons.PloS one · 2015Article
- Kv7 potassium channel subunits and M currents in cultured hippocampal interneurons.Pflugers Archiv : European journal of physiology · 2014Article
- Remote optogenetic activation and sensitization of pain pathways in freely moving mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- MATLAB implementation of a dynamic clamp with bandwidth of >125 kHz capable of generating I Na at 37 °C.Pflugers Archiv : European journal of physiology · 2013Article
- Enhanced excitability of guinea pig inferior mesenteric ganglion neurons during and following recovery from chemical colitis.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
1. Intracellular recordings were made from rat sympathetic neurones in isolated superior cervical ganglia (SCG), coeliac ganglia (CG) and superior mesenteric ganglia (SMG). 2. Based on their response to a maintained depolarizing current stimulus, neurones were classified as 'phasic' or 'tonic'. All neurones in the SCG were phasic, 85% of the neurones in the SMG and 58% of the neurones in the CG were tonic, and the remainder were phasic. 3. The voltage response of phasic and tonic neurones around threshold to a constant current step was markedly different. The response of phasic neurones was biphasic with an initial depolarizing response followed by significant repolarization of the membrane potential. In contrast, tonic neurones became more depolarized during a prolonged current step. 4. The underlying currents were studied using single-electrode voltage-clamp recording. The M-current was present in all phasic neurones, but was very weak or absent in tonic neurones. 5. An A-current was apparent in both phasic and tonic neurones. The voltage-dependent activation, steady- state inactivation, and current density of the A-current were all similar in phasic and tonic cells. 6. A low- threshold, slowly inactivating outward current (D2-current) was observed exclusively in tonic neurones. The slow inactivation of this current appeared to underlie the slow depolarizing ramp seen in response to a maintained depolarizing current step. 7. Computer simulations, based on the voltage-clamp data, suggested that the different firing properties of phasic and tonic neurones could be accounted for by differential expression of the M-current.
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Registered trials
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