ArticleThe EMBO journal1995
Interchromosomal recombination is suppressed in mammalian somatic cells.
Article in The EMBO journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 40 citations in OpenAlex.
- Automated fluorescence intensity and gradient analysis enables detection of rare fluorescent mutant cells deep within the tissue of RaDR mice.Scientific reports · 2018Article
- Translesion synthesis polymerases in the prevention and promotion of carcinogenesis.Journal of nucleic acids · 2010Article
- A strand invasion 3' polymerization intermediate of mammalian homologous recombination.Genetics · 2010Article
- Repair of gaps opposite lesions by homologous recombination in mammalian cells.Nucleic acids research · 2009Article
- Interchromosomal crossover in human cells is associated with long gene conversion tracts.Molecular and cellular biology · 2007Article
- Article
- Sister chromatid gene conversion is a prominent double-strand break repair pathway in mammalian cells.The EMBO journal · 2000Article
- DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis.Oncogene · 1999Review
- Double-strand break-induced recombination between ectopic homologous sequences in somatic plant cells.Genetics · 1999Article
- Evolution of the RECQ family of helicases: A drosophila homolog, Dmblm, is similar to the human bloom syndrome gene.Genetics · 1999Article
- Transgene organization in rice engineered through direct DNA transfer supports a two-phase integration mechanism mediated by the establishment of integration hot spots.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Loss of the maternal H19 gene induces changes in Igf2 methylation in both cis and trans.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Concerted evolution of the tandemly repeated genes encoding human U2 snRNA (the RNU2 locus) involves rapid intrachromosomal homogenization and rare interchromosomal gene conversion.The EMBO journal · 1997Article
- Genotoxicity of aflatoxin B1: evidence for a recombination-mediated mechanism in Saccharomyces cerevisiae.Cancer research · 1996Article
- Requirements for ectopic homologous recombination in mammalian somatic cells.Molecular and cellular biology · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Homologous recombination occurs intrachromosomally as well as interchromosomally, both in mitotic (somatic) cells as well as meiotically in the germline. These different processes can serve very different purposes in maintaining the integrity of the organism and in enhancing diversity in the species. As shown here, comparison of the frequencies of intra- and interchromosomal recombination in meiotic and mitotic cells of both mouse and yeast argues that interchromosomal recombination is particularly low in mitotic cells of metazoan organisms. This result in turn suggests that the recombination machinery of metazoa might be organized to avoid the deleterious effects of homozygotization in somatic cells while still deriving the benefits of species diversification and of DNA repair.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.