ArticleThe EMBO journal1995
X-ray crystallography shows that translational initiation factor IF3 consists of two compact alpha/beta domains linked by an alpha-helix.
Article in The EMBO journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Structural mechanism of mRNA decoding by mammalian GTPase GTPBP1.Nature communications · 2025Article
- Structural mechanism of mRNA decoding by mammalian GTPase GTPBP1.bioRxiv : the preprint server for biology · 2025Article
- Facing the phase problem.IUCrJ · 2023Article
- The dynamic cycle of bacterial translation initiation factor IF3.Nucleic acids research · 2021Article
- A Complementary Mechanism of Bacterial mRNA Translation Inhibition by Tetracyclines.Frontiers in microbiology · 2021Article
- Article
- Article
- Structure of a 30S pre-initiation complex stalled by GE81112 reveals structural parallels in bacterial and eukaryotic protein synthesis initiation pathways.Nucleic acids research · 2017Article
- Conformational Response of 30S-bound IF3 to A-Site Binders Streptomycin and Kanamycin.Antibiotics (Basel, Switzerland) · 2016Article
- Article
- Genomic and transcriptomic analysis of the streptomycin-dependent Mycobacterium tuberculosis strain 18b.BMC genomics · 2016Article
- Initiation of mRNA translation in bacteria: structural and dynamic aspects.Cellular and molecular life sciences : CMLS · 2015Review
- Review
- Anomalous diffraction in crystallographic phase evaluation.Quarterly reviews of biophysics · 2014Review
- Use of europium ions for SAD phasing of lysozyme at the Cu Kα wavelength.Acta crystallographica. Section F, Structural biology and crystallization communications · 2013Article
- Evolutionary and genetic analyses of mitochondrial translation initiation factors identify the missing mitochondrial IF3 in S. cerevisiae.Nucleic acids research · 2012Article
- The natural history of ubiquitin and ubiquitin-related domains.Frontiers in bioscience (Landmark edition) · 2012Review
- The Cryo-EM structure of a complete 30S translation initiation complex from Escherichia coli.PLoS biology · 2011Article
- Structure and Function of the Small MutS-Related Domain.Molecular biology international · 2011Article
- Crystallization and preliminary crystallographic studies of putative RNA 3'-terminal phosphate cyclase from the crenarchaeon Sulfolobus tokodaii.Acta crystallographica. Section F, Structural biology and crystallization communications · 2009Article
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Abstract
The structures of the two domains of translational initiation factor IF3 from Bacillus stearothermophilus have been solved by X-ray crystallography using single wavelength anomalous scattering and multiwavelength anomalous diffraction. Each of the two domains has an alpha/beta topology, with an exposed beta-sheet that is reminiscent of several ribosomal and other RNA binding proteins. An alpha-helix that protrudes out from the body of the N-terminal domain towards the C-terminal domain suggests that IF3 consists of two RNA binding domains connected by an alpha-helix and that it may bridge two regions of the ribosome. This represents the first high resolution structural information on a translational initiation factor.
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