ArticleThe EMBO journal1995
Suppression of PERIOD protein abundance and circadian cycling by the Drosophila clock mutation timeless.
Article in The EMBO journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
83 citing papers in PubMed.
- Post-Translational Modifications in Animal Circadian Clocks.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Article
- The Free-Running Circasemilunar Period Is Determined by Counting Circadian Clock Cycles in the Marine MidgeJournal of biological rhythms · 2024Article
- Functional Analyses of Four Cryptochromes From Aquatic Organisms After Heterologous Expression inJournal of biological rhythms · 2024Article
- Dynamic encoding of temperature in the central circadian circuit coordinates physiological activities.Nature communications · 2024Article
- Circadian rhythms in the Drosophila eye may regulate adaptation of vision to light intensity.Frontiers in neuroscience · 2024Article
- Wolfram syndrome 1 regulates sleep in dopamine receptor neurons by modulating calcium homeostasis.PLoS genetics · 2023Article
- CLOCK and TIMELESS regulate rhythmic occupancy of the BRAHMA chromatin-remodeling protein at clock gene promoters.PLoS genetics · 2023Article
- Sleep Modulates Alcohol Toxicity inInternational journal of molecular sciences · 2022Article
- Clock proteins regulate spatiotemporal organization of clock genes to control circadian rhythms.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Deciphering the Interacting Mechanisms of Circadian Disruption and Alzheimer's Disease.Neurochemical research · 2021Review
- Dissection of central clock function ineLife · 2019Article
- Daywake, an Anti-siesta Gene Linked to a Splicing-Based Thermostat from an Adjoining Clock Gene.Current biology : CB · 2019Article
- Drosophila CrebB is a Substrate of the Nonsense-Mediated mRNA Decay Pathway that Sustains Circadian Behaviors.Molecules and cells · 2019Article
- PERIOD-controlled deadenylation of theProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Spliceosome factors target timeless (eLife · 2018Article
- Reflections on contributing to "big discoveries" about the fly clock: Our fortunate paths as post-docs with 2017 Nobel laureates Jeff Hall, Michael Rosbash, and Mike Young.Neurobiology of sleep and circadian rhythms · 2018Review
- The discoveries of molecular mechanisms for the circadian rhythm: The 2017 Nobel Prize in Physiology or Medicine.Biomedical journal · 2018Article
- How Many Clocks, How Many Times? On the Sensory Basis and Computational Challenges of Circadian Systems.Frontiers in behavioral neuroscience · 2018Review
- A 50-Year Personal Journey: Location, Gene Expression, and Circadian Rhythms.Cold Spring Harbor perspectives in biology · 2017Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The timeless mutation (tim) leads to loss of circadian behavioral rhythms in Drosophila melanogaster. The effects of tim on rhythmicity involve interactions with period (per), a second essential clock gene, as the tim mutation suppresses circadian oscillations of per transcription and blocks nuclear localization of a PER reporter protein. In the present study it was found that the tim mutant constitutively produces a low level of PER protein that is comparable with that produced late in the day by wild-type flies. In addition, it was shown that tim suppresses circadian cycling of PER protein abundance and circadian regulation of PER phosphorylation. Transfer of wild-type flies to constant light also suppressed cycling of PER abundance and phosphorylation and produced constitutively low levels of PER. In the tim mutant there was no additional effect of constant light on PER. These results suggest that constant light and the tim mutation produce related changes in the underlying biological clock. We further suggest that the multiple effects of tim are due to a primary effect on per expression at the posttranscriptional level. The effects of tim on behavioral rhythms and per RNA cycling are therefore likely to involve effects on PER protein through previously proposed feedback mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.