ArticleThe EMBO journal1995
The PMR2 gene cluster encodes functionally distinct isoforms of a putative Na+ pump in the yeast plasma membrane.
Article in The EMBO journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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Who cites it
75 citing papers in PubMed.
- Strategic targeting of Cas9 nickase expands tandem gene arrays.Cell genomics · 2025Article
- The Saccharomyces cerevisiae ∑1278b strain is sensitive to NaCl because of mutations in its ENA1 gene.FEMS yeast research · 2025Article
- Exit, O Sodium!Function (Oxford, England) · 2024Article
- Quantifying turgor pressure in budding and fission yeasts based upon osmotic properties.Molecular biology of the cell · 2023Article
- Integrated genomics and phenotype microarray analysis of Saccharomyces cerevisiae industrial strains for rice wine fermentation and recombinant protein production.Microbial biotechnology · 2023Article
- Quantifying turgor pressure in budding and fission yeasts based upon osmotic properties.bioRxiv : the preprint server for biology · 2023Article
- Gene-by-environment interactions influence the fitness cost of gene copy-number variation in yeast.G3 (Bethesda, Md.) · 2023Article
- Inferring sparse structure in genotype-phenotype maps.Genetics · 2023Article
- Gene-by-environment interactions influence the fitness cost of gene copy-number variation in yeast.bioRxiv : the preprint server for biology · 2023Article
- TheInternational journal of molecular sciences · 2023Article
- Barcoded bulk QTL mapping reveals highly polygenic and epistatic architecture of complex traits in yeast.eLife · 2022Article
- Catalytically inactive Cas9 impairs DNA replication fork progression to induce focal genomic instability.Nucleic acids research · 2021Article
- Review
- Independent Mechanisms for Acquired Salt Tolerance versus Growth Resumption Induced by Mild Ethanol Pretreatment inmSphere · 2018Article
- Four Saccharomyces species differ in their tolerance to various stresses though they have similar basic physiological parameters.Folia microbiologica · 2018Article
- Physiological and transcriptomic analysis of a salt-resistant Saccharomyces cerevisiae mutant obtained by evolutionary engineering.Bosnian journal of basic medical sciences · 2018Article
- Natural Variation inG3 (Bethesda, Md.) · 2018Article
- Towards a Unified Understanding of Lithium Action in Basic Biology and its Significance for Applied Biology.The Journal of membrane biology · 2017Review
- The adaptive landscape of wildtype and glycosylation-deficient populations of the industrial yeast Pichia pastoris.BMC genomics · 2017Article
- Massive Amplification at an Unselected Locus Accompanies Complex Chromosomal Rearrangements in Yeast.G3 (Bethesda, Md.) · 2016Article
15 more citing papers are in PubMed but not listed here.
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5 authors.
Funding
Abstract
We report a structural and functional analysis of the PMR2 gene cluster in yeast. We found that several strains of Saccharomyces cerevisiae contain multiple PMR2 genes repeated in tandem, whereas most phylogenetically related yeasts appear to possess only a single PMR2 gene. This unusual tandem array of nearly identical genes encodes putative ion pumps involved in Na+ tolerance. Pmr2a and Pmr2b, the proteins encoded by the first two repeats, differ by only 13 amino acid exchanges. Both proteins share localization to the plasma membrane, but represent distinct isoforms of a putative Na+ pump. When expressed under identical conditions in vivo, Pmr2a and Pmr2b cause different tolerances to Na+ and Li+. Finally, we show that the Na+ tolerance mediated through these pumps is regulated by calmodulin via a calcineurin-independent mechanism which activates the Pmr2 ion pumps post-transcriptionally.
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