ArticleClinical and experimental immunology1995
Increased dimeric IgA-producing B cells in tonsils in IgA nephropathy determined by in situ hybridization for J chain mRNA.
Article in Clinical and experimental immunology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 56 citations in OpenAlex.
- IgA class-switched CD27-CD21+ B cells in IgA nephropathy.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Article
- IgA Nephropathy: Pleiotropic impact of Epstein-Barr virus infection on immunopathogenesis and racial incidence of the disease.Frontiers in immunology · 2023Review
- The Role of Immune Modulation in Pathogenesis of IgA Nephropathy.Frontiers in medicine · 2020Review
- Role of Epstein-Barr Virus in Pathogenesis and Racial Distribution of IgA Nephropathy.Frontiers in immunology · 2020Article
- A New Vision of IgA Nephropathy: The Missing Link.International journal of molecular sciences · 2019Review
- The epipharynx-kidney axis triggers glomerular vasculitis in immunoglobulin A nephropathy.Immunologic research · 2019Review
- Multiple rare genetic variants co-segregating with familial IgA nephropathy all act within a single immune-related network.Journal of internal medicine · 2017Article
- New Insights into the Pathogenesis of IgA Nephropathy.Kidney diseases (Basel, Switzerland) · 2015Article
- Genetics and immunopathogenesis of IgA nephropathy.Clinical reviews in allergy & immunology · 2011Review
- Immunopathogenesis of IgAN.Seminars in immunopathology · 2007Review
- Dysregulated LIGHT expression on T cells mediates intestinal inflammation and contributes to IgA nephropathy.The Journal of clinical investigation · 2004Article
- Expression of T cell receptor variable region families by bone marrow gammadelta T cells in patients with IgA nephropathy.Clinical and experimental immunology · 2002Article
- Enhanced expression of L-selectin on peripheral blood lymphocytes from patients with IgA nephropathy.Clinical and experimental immunology · 1999Article
- A comparative study of digoxigenin, 2,4-dinitrophenyl, and alkaline phosphatase as deoxyoligonucleotide labels in non-radioisotopic in situ hybridisation.Journal of clinical pathology · 1997Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
The origin of mesangial IgA deposits in IgA nephropathy (IgAN) remains obscure. A significant proportion of deposited immunoglobulin is dimeric (J chain-positive). Previous studies of J chain expression within lymphoid tissue in IgAN have utilized antibodies which other investigators have found to be non-specific. To address this problem, we have developed and in situ hybridization (ISH) method for the detection of J chain mRNA within IgA plasma cells. Tonsils from 12 patients with IgAN and 12 controls were studied using (i) non-isotopic ISH for J chain mRNA, and (ii) combined immunofluorescence (IF) and fluorescent ISH. J chain mRNA-positive cells were identified in germinal centres, and within the subepithelial and interfollicular zones. A greater number of J chain mRNA-positive cells were found in the germinal centres of patients (mean 57.7 +/- 4.6 cells/10(5) micron2) compared with controls (mean 36.9 +/- 3.5 cells/10(5) micron2) (P < 0.001). Combined IF and fluorescent ISH showed a greater proportion of J chain mRNA-positive interfollicular IgA cells in patient tonsils (32 +/- 3.4%) compared with controls (21 +/- 2.3%; P < 0.02). These results indicate a shift towards dimeric IgA production in the tonsils in IgAN. In addition, the finding of excess numbers of J chain-positive Iga-negative cells within germinal centres suggests that an abnormality may be present at the B cell differentiation stage before IgA switching. These results further highlight immune abnormalities within the tonsil as a central feature of abnormal polymeric IgA biology in this common form of glomerulonephritis.
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