ReviewAmerican journal of public health1995
Apolipoprotein E and Alzheimer's disease: the implications of progress in molecular medicine.
Review in American journal of public health, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Predictive Genetic Counseling for Neurodegenerative Diseases: Past, Present, and Future.Cold Spring Harbor perspectives in medicine · 2020Review
- ApoE4-associated phospholipid dysregulation contributes to development of Tau hyper-phosphorylation after traumatic brain injury.Scientific reports · 2017Article
- A case of inappropriate apolipoprotein e testing in Alzheimer's disease due to lack of an informed consent discussion.American journal of Alzheimer's disease and other dementias · 2014Article
- Mild parkinsonian signs are associated with increased risk of dementia in a prospective, population-based study of elders.Movement disorders : official journal of the Movement Disorder Society · 2010Article
- Why should primary care physicians know about the genetics of dementia?The Western journal of medicine · 2001Review
- Disturbance of cerebral function in people exposed to drinking water contaminated with aluminium sulphate: retrospective study of the Camelford water incident.BMJ (Clinical research ed.) · 1999Article
- Evidence for major gene inheritance of Alzheimer disease in families of patients with and without apolipoprotein E epsilon 4.American journal of human genetics · 1996Article
- Nonconsensual participation in genetic studies.American journal of public health · 1996Article
- Genetic prophecy and genetic privacy--can we prevent the dream from becoming a nightmare?American journal of public health · 1995Article
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Authors and funding
2 authors.
Funding
Abstract
We review the current status as well as the risks and benefits of a recently developed DNA test of risk for Alzheimer's disease: the apolipoprotein E genotype. While apolipoprotein E genotypes may indicate a degree of susceptibility, the gene is neither necessary nor sufficient to cause the disease; thus, many questions remain. Because risk prediction is not straightforward, practical issues related to the testing of complex diseases like Alzheimer's and to the ethical, legal, and social implications of genetic tests require careful consideration and unambiguous answers. The use of apolipoprotein E genotyping in patients with Alzheimer's disease should be limited to research centers, and additional studies are strongly recommended. Apolipoprotein E genotypes should not be available to third parties such as insurers or employers until genotypic risks are fully understood. National policies that encourage scientific investigation while maintaining individual privacy and limiting unnecessary access to genetic information should be immediately developed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.