ArticleNucleic acids research1995
Activation of a muscle-specific enhancer by the Ski proto-oncogene.
Article in Nucleic acids research, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 41 citations in OpenAlex.
- Combined cistrome and transcriptome analysis of SKI in AML cells identifies SKI as a co-repressor for RUNX1.Nucleic acids research · 2018Article
- Adaptive introgression from distant Caribbean islands contributed to the diversification of a microendemic adaptive radiation of trophic specialist pupfishes.PLoS genetics · 2017Article
- Ski regulates muscle terminal differentiation by transcriptional activation of Myog in a complex with Six1 and Eya3.The Journal of biological chemistry · 2009Article
- Defective T-cell activation is associated with augmented transforming growth factor Beta sensitivity in mice with mutations in the Sno gene.Molecular and cellular biology · 2003Article
- Review
- Ski interacts with the evolutionarily conserved SNW domain of Skip.Nucleic acids research · 2001Article
- Ski acts as a co-repressor with Smad2 and Smad3 to regulate the response to type beta transforming growth factor.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling.Genes & development · 1999Article
- Transformation of hematopoietic cells by the Ski oncoprotein involves repression of retinoic acid receptor signaling.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Trans-regulation of myogenin promoter/enhancer activity by c-ski during skeletal-muscle differentiation: the C-terminus of the c-Ski protein is essential for transcriptional regulatory activity in myotubes.The Biochemical journal · 1997Article
- DNA binding and transcriptional activation by the Ski oncoprotein mediated by interaction with NFI.Nucleic acids research · 1997Article
- Mice lacking the ski proto-oncogene have defects in neurulation, craniofacial, patterning, and skeletal muscle development.Genes & development · 1997Article
- Transcriptional cofactors Ski and SnoN are major regulators of the TGF-β/Smad signaling pathway in health and disease.Signal transduction and targeted therapyArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
In transgenic mice, muscle-specific expression of the c-ski oncogene induces hypertrophy exclusively in a subset of fast muscle fibers. Here we report that regulatory elements from two genes expressed in fast fibers, myosin light chain 1/3 (MLC) and muscle creatine kinase (MCK), were activated when co-transfected with c-ski expression vectors in myoblasts. The expression from the MLC enhancer was reduced when the c-ski oncogene was cotransfected with MyoD into NIH3T3 fibroblasts. Activation of the MLC enhancer by Ski also occurred in vivo, since bigenic progeny generated by mating MLC-CAT and MSV-skitransgenic mice displayed higher CAT activity in their muscles than did the MLC-CAT parental line. Identification of gene targets for the fiber-specific action of the c-ski gene product provides a molecular model that could be used for the further dissection of Ski-induced hypertrophy, both in tissue culture and in vivo.
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Registered trials
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