ArticleNucleic acids research1995
Use of a mammalian interspersed repetitive (MIR) element in the coding and processing sequences of mammalian genes.
Article in Nucleic acids research, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 38 citations in OpenAlex.
- Coevolution Theory of the Genetic Code at Age Forty: Pathway to Translation and Synthetic Life.Life (Basel, Switzerland) · 2016Article
- Feature co-localization landscape of the human genome.Scientific reports · 2016Article
- Article
- Tracking the past: interspersed repeats in an extinct Afrotherian mammal, Mammuthus primigenius.Genome research · 2009Article
- Weak preservation of local neutral substitution rates across mammalian genomes.BMC evolutionary biology · 2009Article
- Exon creation and establishment in human genes.Genome biology · 2008Article
- Discovery of a novel murine type C retrovirus by data mining.Journal of virology · 2001Article
- Article
- A novel family of repeat sequences in the mouse genome responsive to retinoic acid.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
- Reverse transcriptase: mediator of genomic plasticity.Virus genes · 1995Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mammalian interspersed repetitive (MIR) element was amplified in mammals 130 million years ago. The MIR element is at least 260 bp in length and is found in approximately 105 copies in the mammalian genome. We analyzed copies of the MIR element in the DNA of various mammals to determine its relationship to the structure and function of genes, in an attempt to identify specific uses of the MIR element within the mammalian genome. We found that alternative splicing within the acetylcholine receptor gene in humans takes place within the MIR element and results in the incorporation of part of the MIR element into the coding sequence of this gene. Furthermore, the polyadenylation signal (AATAAA) at the 3' end of four different mammalian genes is derived from the MIR element. These uses of the MIR element suggest that other regulatory sequences found within the mammalian genome originated from ancient transposable elements, many of which may no longer be recognizable.
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